Elsevier

The Lancet

Volume 342, Issue 8877, 16 October 1993, Pages 961-962
The Lancet

Short reports
Aerosolised prostacyclin in adult respiratory distress syndrome

https://doi.org/10.1016/0140-6736(93)92004-DGet rights and content

Abstract

We studied the effects of aerosolised prostacyclin (PGI2) in three patients with acute severe adult respiratory distress syndrome. 17–50 ng/kg per min, nebulised into the afferent limb of the ventilator circuit, decreased mean pulmonary artery pressure (SEM) from 40·3 (13·5) to 32·0 (3·8) mm hg (pulmonary vascular resistance fell by 30%); systemic arterial pressure decreased slightly from 76·8 (2·2) to 74·5 (6·1) mm hg. Concomitantly, the ratio of arterial oxygen partial pressure to the fraction of inspired oxygen increased from 120 (19) to 173 (18), mainly due to redistribution of blood flow from shunt areas to regions of normal ventilation-perfusion. All effects were reversed on drug withdrawal. Lancet 1993; 342: 961–62

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