Elsevier

International Journal of Pharmaceutics

Volume 6, Issues 3–4, September–October 1980, Pages 295-300
International Journal of Pharmaceutics

Research paper
Fraction of dose exhaled after administration of pressurized inhalation aerosols

https://doi.org/10.1016/0378-5173(80)90112-XGet rights and content

Abstract

After the administration of a pressurized inhalation aerosol, a fraction of the dose will be lost with the exhaled air. In the present study suspension aerosols containing a freely water-soluble drug, terbutaline sulphate, and a practically insoluble drug, budesonide, were administered to 10 healthy subjects. The air flow rate, the tidal volume, and the moment of actuation were registered for each of the inhaled doses. The exhalation was performed without any breath-holding pause. The drug in the exhaled air was collected on a membrane filter and in an absorbing solution. The fraction of the dose lost with the exhaled air was less than 1% for both drugs. Differences in air flow rate and tidal volume did not affect the results. A particle growth due to moisture absorption did not appear to be important for the total drug deposition in the respiratory tract

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