Is the correct use of a dry powder inhaler (Turbohaler) age dependent?☆,☆☆
Section snippets
Patients
All children attending the asthma outpatient clinic were consecutively included in this study, provided that they had never used a dry powder inhaler and were 5 years of age or older.
Study design
The Turbohaler-trainer is a device simulating the Turbohaler and allowing a semiquantitative measurement of peak inspiratory flow (PIF). Activation of 0, 1, 2, and 3 light-emitting diodes (LEDs) are reported to correspond to flows less than 20, 21 to 40, 41 to 60, and more than 60 L·min–1, respectively. This report
First assessment
A first assessment of Turbohaler use was done in 166 children attending the asthma clinic. Of them, 5 could not perform pulmonary function tests and therefore were excluded from further evaluation. The mean age of these patients was 6.8 years (range, 6.3 to 7.4 years). One hundred sixty-one children (94 boys and 67 girls), ranging in age from 5 to 17 years (Table I), comprised the study group.One hundred thirty three of these 161 (83%) children could perform every step correctly. Of 28 children
DISCUSSION
Nearly all children 8 years of age and older could be easily taught to correctly use a Turbohaler device; in about half of the children below that age were we able to do so. Those who used the device correctly continued to do so on follow-up. The restrictions to optimal use were the inability to generate sufficient inspiratory flow through the Turbohaler and the inability to correctly prepare a drug dose. The latter could be performed by a parent, thereby increasing the proportion of possible
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Cited by (53)
The impact of inhaler technique on clinical outcomes in adolescents and adults with asthma: A systematic review
2022, Respiratory MedicineCitation Excerpt :Information on asthma severity at baseline was provided in only three studies [28,47,54], with patients being characterised as having moderate-to-severe disease. Fifteen studies reported the proportion of patients with incorrect inhaler technique [8,22,23,27,28,30,31,33,36,37,43,44,53–55], of which 9 (60%) evaluated both Turbuhaler and Diskus devices [8,22,23,27,28,31,37,44,55]. Eleven studies evaluated the association between incorrect technique and clinical burden, patient-reported outcomes, cost or healthcare resource utilization [8,22,24,26,34,36,44,45,48,49,52].
Dry powder inhaler aerosol deposition in a model of tracheobronchial airways: Validating CFD predictions with in vitro data
2020, International Journal of PharmaceuticsCitation Excerpt :However, Deposition patterns of the MDI and DPI devices were similar. De Boeck et al. (1999), carried out a study on the relationship of subject’s age and correct usage of DPI using a large population of children aged 5–17 (De Boeck et al., 1999). After a little training, more than 80% of the participants performed every step of the process correctly.
Technological and practical challenges of dry powder inhalers and formulations
2014, Advanced Drug Delivery ReviewsMicron particle deposition in a tracheobronchial airway model under different breathing conditions
2010, Medical Engineering and Physics
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Reprint requests: Kris De Boeck, MD, PhD, Pediatric Pulmonology, Department of Pediatrics, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.
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