Elsevier

The Lancet

Volume 278, Issue 7218, 30 December 1961, Pages 1428-1432
The Lancet

ORIGINAL ARTICLES
PROPHYLACTIC USE OF INFLUENZA VACCINE IN PATIENTS WITH CHRONIC BRONCHITIS: A Pilot Trial

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      The Advisory Committee on Immunization Practices (ACIP) also recommended that all patients with COPD obtain the influenza vaccination annually.9 These recommendations stemmed from several observational and randomized studies that demonstrated the efficacy and cost-effectiveness of influenza vaccine in decreasing the number of acute exacerbations, hospitalization, occurrence of pneumonia, and risk of death.10–13 However, despite the documented effectiveness of the vaccine14 and the numerous recommendations to give influenza vaccination to patients with COPD, annual vaccination coverage is still low.15–18

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      This systematic review evaluated the evidence from RCTs regarding treatment effects of influenza vaccination in subjects with COPD, including exacerbation rates, hospitalizations, mortality, lung function, and adverse effects.58 Eleven studies were included in this systematic, evidence-based review, with six specifically performed in patients with COPD and two evaluating exacerbation rates using inactivated virus vaccination.59,60 These studies defined COPD minimally by specified COPD clinical diagnosis and measured exacerbations determined clinically without rigorous or adjudicated definitions.

    • Influenza vaccination among Canadians with chronic respiratory disease

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      Influenza infection is estimated to account for 10–30% of exacerbations of asthma1–3 and chronic obstructive pulmonary disease (COPD).4–8

    • Targeting the COPD Exacerbation

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