POSITIVE END-EXPIRATORY PRESSURE IN WEANING PATIENTS FROM CONTROLLED VENTILATION: A Prospective Randomised Trial
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Higher PEEP versus lower PEEP strategies for patients in ICU without acute respiratory distress syndrome: A systematic review and meta-analysis
2022, Journal of Critical CareCitation Excerpt :Among the studies presented in Supplementary Table 1, in the high PEEP group, PEEP ranged from 5 to 30 cm H2O, while in the low PEEP group, PEEP ranged from 0 to 10 cm H2O. Ten studies used ZEEP (defined as 0 cm H2O PEEP) as a comparative group, and most of them were published earlier [3,10,17,19-24,29]. Patients in ICU requiring PEEP were medical patients (including those with ARF, trauma, neurogenic pulmonary edema (NPE), etc.), postoperative patients (most of whom had undergone cardiac surgery) or mixed patients (containing medical and postoperative patients), and the number of participants ranged from 15 to 969.
Effect of different levels of PEEP on mortality in ICU patients without acute respiratory distress syndrome: systematic review and meta-analysis with trial sequential analysis
2021, Journal of Critical CareCitation Excerpt :And eight of twenty-seven RCTs used P/F ratio or SpaO2 to set PEEP between these two groups [8,29,30,43,44,47,48,53]. The rest of studies set PEEP according to predefined protocol [31-35,37-42,45,46,49-52,54]. Regarding the risk of bias of individual RCTs, six studies were judged as low risk of bias [8,30,34,39,41,46].
Modalities of spontaneous breathing trials
2001, ReanimationTrials comparing alternative weaning modes and discontinuation assessments
2001, ChestCitation Excerpt :The sample size of the eight randomized studies of discontinuation assessment strategy modes varied from 18 to 526. Three of the studies enrolled > 100 patients (Table 1).1516171819202122 The largest studies2122 were methodologically strong, reporting the method of randomization and weaning, extubation, and reintubation criteria.