Case ReportsRelapsing Rhodococcus equi infection in a heart transplant recipient successfully treated with long-term linezolid
Section snippets
Case report
We report a 55-year-old man suffering from hypertension and diabetes mellitus who received a heart transplant in April 1999. He developed chronic rejection and received a 2nd transplant in August 2001. Despite prophylaxis with ganciclovir, itraconazole, and cotrimoxazole, he experienced severe postsurgical infectious complications (bacteremic mediastinitis, Staphylococcus aureus pneumonia, and cytomegalovirus [CMV] viremia) from which he recovered successfully. He was discharged and returned to
Acknowledgments
The authors thank Thomas O'Boyle for his help in the translation of the article.
This study does not present any conflict of interest for its authors.
This study was partially financed by a grant from the Spanish Social Security Health Investigation Fund (CIBER Enfermedades Respiratorias CB06/06/0058), Instituto de Salud Carlos III, and from Fundación Mutua Madrileña, Madrid, Spain.
Jesús Guinea, Pharm D, PhD, is contracted by Fondo de Investigación Sanitaria (FIS) CM05/00171, Madrid, Spain.
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Rhodococcus hoagii bloodstream infection in an allogeneic hematopoietic stem cell transplantation patient: Case report and review of literature
2020, IDCasesCitation Excerpt :This clinician characteristic makes the diagnostic hypothesis even more challenging. Most of the cases reported in transplantation patients described the lung as the mainly route of infection [4,6–17]. Around 80 % developed pulmonary cavity, and among immunocompromised populations, it is often observed disseminated disease as well [1].
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2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious DiseasesMultidrug-resistant bacterial infection in solid organ transplant recipients
2012, Enfermedades Infecciosas y Microbiologia ClinicaPrimary retroperitoneal abscesses due to Rhodococcus equi in a patient with severe nephrotic syndrome: successful antibiotic treatment with linezolid and tigecycline
2010, International Journal of Infectious DiseasesCitation Excerpt :Little is known about the efficacy of these two antibiotics in the treatment of R. equi infections. Linezolid has some in vitro activity9 and a successful treatment of R. equi pneumonia in a heart transplant recipient has been described.21 Tigecycline has been reported to show good in vitro activity against R. equi,22 but clinical experience is still lacking.
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2010, The Lancet Infectious DiseasesRhodoccocus Equi pneumonia and paradoxical immune reconstitution inflammatory syndrome in a patient with acquired immune deficiency syndrome (AIDS)
2017, American Journal of Case Reports
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CIBER ENFERMEDADES RESPIRATORIAS CB06/06/0058.