Featured clinical trialInterval versus continuous training in lung transplant candidates: A randomized trial
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Methods and materials
This study was approved by the Bavarian Ethics Committee (identification number 08022) and registered on the Clinical Trials registry (identification number NCT00962078).
Baseline characteristics
Sixty of 71 patients completed the study (for drop-out reasons see Figure 1) and were considered for the final per-protocol analysis. Owing to the advanced stage of the disease, patients showed an extreme limitation of respiratory capacities (baseline values see Table 1). Mean forced expiratory volume at 1 second (FEV1) was 25% ± 8% of predicted value on admission. Furthermore a low Tiffeneau Index (FEV1/inspiratory vital capacity) of 35% ± 8% predicted, as well as a low diffusion capacity if
Discussion
Former trials investigating different endurance training protocols mostly included patients with COPD at GOLD stages II to III with FEV1 values between 33% and 55% predicted.14, 25, 26, 27, 28, 29 Our study extended these findings to the GOLD stage IV by revealing that exercise training is also effective in very disabled COPD patients before LTx.
IT and CT can both induce comparable effects in exercise capacity. These findings are in line with results of previous studies. Puhan et al26
Disclosure statement
The authors thank Dominica Holle, Andreas Zech, Inga Heinzelmann, Regina Dittmann-Ontivero, Ulrike Hornung, Jessica Wendl, Jens Boensch, Andreas Brandner, and Thomas Damisch, from the Department of Sports Therapy, and Wanda Tamerl, Monika Jell, and their staff, from the Department of Clinical Diagnostics, for assistance with data collection. The authors thank Dr Bernd Sczepanski and Dr Sandra Winterkamp for the medical care of the patients. Special thanks to Dr Tibor Schuster from the
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