Asthma and lower airway diseaseDecreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use
Section snippets
Subjects
Children with asthma referred to National Jewish Health were identified through focused searches of laboratory data using codes for the 25-hydroxyvitamin D assay. Data were collected between April 1, 2008, and October 31, 2009. Patients' medical information was obtained by using the National Jewish Health electronic medical record and the National Jewish Research Database.13 Patients between the ages of 0 and 18 years who had 25-hydroxyvitamin D serum levels (used interchangeably with VitD
Subjects' characteristics
25-Hydroxyvitamin D levels and clinical features were analyzed in a total of 100 children with asthma aged 0 to 18 years (Table I). Racial data were available for 81 of the subjects. Seventy-nine percent of the participants were white, 9% were American Indian or Alaska Native (including Hispanic), 6% were African American, 3% were Asian, and 4% were of reported mixed race (data not shown).17 The median latitude was 39.0°N. The median eosinophil counts and total IgE levels were 311 cells/mm3 and
Discussion
In our population of pediatric patients with asthma, who were primarily from latitudes above 35°N, the prevalence of VitD insufficiency (<30 ng/mL) was 47%, with 17% of patients being VitD deficient (<20 ng/mL). These percentages were higher than in a recent study involving childhood asthma and VitD that was done in an equatorial population from Costa Rica, in which 28% had VitD insufficiency.12 The majority of our patients (79%) had VitD levels collected during a time period in which cutaneous
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Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.