Original ArticleChildhood Cancer Following Neonatal Oxygen Supplementation
Section snippets
Methods
The Collaborative Perinatal Project (CPP) enrolled approximately 48,000 women, who had about 60,000 pregnancies, at 12 university-affiliated medical centers between 1959 and 1966; study design and data collection procedures have been described elsewhere.6 Briefly, trained observers in delivery rooms recorded the details of 54,795 live births using a standardized methodology. Children received multiple physical examinations in the first year of life and again at age 7 years. Parents were
Results
Table II summarizes the number of cases, child-months, and hazard ratios (HRs) for the potential confounders. There were no statistically significant associations of cancer with family socioeconomic index, maternal education or age, or child's race, birth weight, or gestational age. Only 1-minute Apgar score < 7 was significantly associated with childhood cancer (HR = 2.22; 95% confidence interval [CI] = 1.19 to 4.13).
Table III summarizes the number of cases, child-months, and HRs for dichotomous O2
Discussion
We found a significantly increased rate of childhood cancer diagnosed between the first week of life and age 8 years among children who received O2 for 3 minutes or longer. This finding was robust to adjustment for various risk factors for childhood cancer.12 The HR for receipt of 3 or more minutes of O2 was not significant (P = .10) but was still elevated when analysis was restricted to cancers diagnosed after age 1 year, to rule out the possibility that O2 was given in response to the symptoms
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Cited by (0)
Supported by the University of Minnesota Children's Cancer Research Fund.