Abstract
Although we have drugs and biologics designed to interfere with the innate immune response, none has been shown to shut down the massive inflammatory reaction that occurs during sepsis. A new pro-inflammatory myeloid-cell receptor might make a better target.
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References
Bernard, G.R. et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N. Engl. J. Med. 344, 699–709 (2001).
Bouchon, A., Facchetti, A., Weigand, M.A. & Colonna, M. Nature, (in the press).
Bouchon, A., Dietrich, J. & Colonna, M. Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J. Immunol. 164, 4991–4995 (2000).
Thiebelmont, N. & Wright, S.D. Transport of bacterial lipopolysaccharide to the golgi apparatus. J. Exp. Med. 190, 523–534 (1999).
Kaisho, T. & Akira, S. Critical roles of Toll-like receptors in host defense. Crit. Rev. Immunol. 20, 393–405 (2000).
Jin, F.-Y., Nathan, C.F. & Ding, A. Paradoxical preservation of a lipopolysaccharide response in C3H/HeJ macrophages: induction of matrix metalloproteinase-9. J. Immunol. 162, 3596–3600 (1999).
Byrd, C.A. et al. Heat shock protein 90 mediates macrophage activation by taxol and bacterial lipopolysaccharide. Proc. Natl. Acad. Sci. USA 96, 5645–5650 (1999).
Triantafilou, K. et al. A CD14-independent LPS receptor cluster. Nature Immunol. 2, 338–345 (2001).
Inohara, N., Ogura, Y. Chen, F.F., Muto, A. & Nuñez, G. Human Nod1 confers responsiveness to bacterial lipopolysaccharides. J. Biol. Chem. 276, 2551–2554 (2001).
Perera, P.Y. et al. CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J. Immunol. 166, 574–581 (2001).
Grobmyer, S. R. et al. Peptidomimetic fluoromethylketone rescues mice from lethal endotoxic shock: Paradoxical increase in products of caspase 1 (ICE). Mol. Med. 5, 585–594 (1999).
Wang, H. et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285, 248–251 (1999).
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Nathan, C., Ding, A. TREM-1: A new regulator of innate immunity in sepsis syndrome. Nat Med 7, 530–532 (2001). https://doi.org/10.1038/87846
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DOI: https://doi.org/10.1038/87846
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