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Crossover Trial Comparing Pressure Support With Synchronized Intermittent Mandatory Ventilation

Journal of Perinatology volume 22, pages 461–466 (2002)Cite this article

Abstract

OBJECTIVE: To compare pressure support ventilation (PSV) with volume guarantee (VG) to synchronized intermittent mandatory ventilation (SIMV) in infants with respiratory distress syndrome (RDS).

STUDY DESIGN: A randomized, crossover study design was used. We enrolled 14 infants [BW (mean±SD) 2.5±0.7 kg, GA 34±2 weeks, age 49±26 hours]. Subjects received 4 hours of each mode of ventilation, with the first mode selected randomly. End expiratory volume (EEV) was measured during both ventilatory modes.

RESULTS: Minute ventilation was greater with PSV+VG than with SIMV (p=0.012). This occurred despite no difference in paCO2. Mean airway pressure was higher during PSV+VG (p=0.023). There was no difference in the arterial/alveolar oxygen tension (a/A) ratio or in the specific dynamic compliance (sCdyn).

CONCLUSION: Because of an increase in VE with PSV+VG, and no difference in the a/A ratio or sCdyn, we do not recommend the routine use of PSV+VG for this population.

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Acknowledgements

We acknowledge the assistance in statistical analysis offered by Stephen Simon, PhD, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine (Kansas City, MO). Supported by Children's Mercy Hospital Research and Education Award (S. L. O.), Children's Mercy Hospital Physician Scientist Award (W. E. T.), and computer software upgrade support from Drager.

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Authors and Affiliations

  1. Department of Pediatrics, Section of Neonatology, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA

    Steven L Olsen MD, Donald W Thibeault MD & William E Truog MD

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  1. Steven L Olsen MD
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  2. Donald W Thibeault MD
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  3. William E Truog MD
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Additional information

This work was presented at Pediatric Academic Societies Meeting, Baltimore, MD, 2001.

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Olsen, S., Thibeault, D. & Truog, W. Crossover Trial Comparing Pressure Support With Synchronized Intermittent Mandatory Ventilation. J Perinatol 22, 461–466 (2002). https://doi.org/10.1038/sj.jp.7210772

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