Noninvasive Ventilation for Patients with Hypoxemic Acute Respiratory Failure

 

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Abstract

Noninvasive ventilation (NIV) has an established efficacy to improve gas exchange and reduce the work of breathing in patients with hypoxemic acute respiratory failure. The clinical efficacy in terms of meaningful outcome is less clear and depends very much on patient selection and assessment of the risks of the technique. The potential risks include an insufficient reduction of the oxygen consumption of the respiratory muscles in case of shock, an excessive increase in tidal volume in case of lung injury, and a risk of delayed or emergent intubation. With a careful selection of patients and a rapid decision regarding the need for intubation in case of failure, great benefits can be offered to patients. Emerging indications include its use in patients with treatment limitations, in the postoperative period, and in patients with immunosuppression. This last indication will necessitate reappraisal because the prognosis of the conditions associated with immunosuppression has improved over the years. In all cases, there is both a time window and a severity window for NIV to work, after which delaying endotracheal intubation may worsen outcome. The preventive use of NIV seems promising in this setting but needs more research. An emerging interesting new option is the use of high flow humidified oxygen, which seems to be intermediate between oxygen alone and NIV.

• References

• 1 Evans TW. International Consensus Conferences in Intensive Care Medicine: non-invasive positive pressure ventilation in acute respiratory failure. Organised jointly by the American Thoracic Society, the European Respiratory Society, the European Society of Intensive Care Medicine, and the Société de Réanimation de Langue Française, and approved by the ATS Board of Directors, December 2000. Intensive Care Med 2001; 27 (1) 166-178
  CrossrefPubMedGoogle Scholar
• 2 Terzi N, Piquilloud L, Rozé H , et al. Clinical review: Update on neurally adjusted ventilatory assist - report of a round-table conference. Crit Care 2012; 16 (3) 225
  CrossrefPubMedGoogle Scholar
• 3 Keenan SP, Gregor J, Sibbald WJ, Cook D, Gafni A. Noninvasive positive pressure ventilation in the setting of severe, acute exacerbations of chronic obstructive pulmonary disease: more effective and less expensive. Crit Care Med 2000; 28 (6) 2094-2102
  CrossrefPubMedGoogle Scholar
• 4 Mascheroni D, Kolobow T, Fumagalli R, Moretti MP, Chen V, Buckhold D. Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study. Intensive Care Med 1988; 15 (1) 8-14
  CrossrefPubMedGoogle Scholar
• 5 Rana S, Jenad H, Gay PC, Buck CF, Hubmayr RD, Gajic O. Failure of non-invasive ventilation in patients with acute lung injury: observational cohort study. Crit Care 2006; 10 (3) R79
  CrossrefPubMedGoogle Scholar
• 6 L'Her E, Deye N, Lellouche F , et al. Physiologic effects of noninvasive ventilation during acute lung injury. Am J Respir Crit Care Med 2005; 172 (9) 1112-1118
  CrossrefPubMedGoogle Scholar
• 7 Carlucci A, Richard JC, Wysocki M, Lepage E, Brochard L. SRLF Collaborative Group on Mechanical Ventilation. Noninvasive versus conventional mechanical ventilation. An epidemiologic survey. Am J Respir Crit Care Med 2001; 163 (4) 874-880
  CrossrefPubMedGoogle Scholar
• 8 Demoule A, Girou E, Richard JC, Taillé S, Brochard L. Increased use of noninvasive ventilation in French intensive care units. Intensive Care Med 2006; 32 (11) 1747-1755
  CrossrefPubMedGoogle Scholar
• 9 Esteban A, Anzueto A, Frutos F , et al; Mechanical Ventilation International Study Group. Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 2002; 287 (3) 345-355
  CrossrefPubMedGoogle Scholar
• 10 Esteban A, Ferguson ND, Meade MO , et al; VENTILA Group. Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med 2008; 177 (2) 170-177
  CrossrefPubMedGoogle Scholar
• 11 Esteban A, Frutos-Vivar F, Muriel A , et al. Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med 2013; 188 (2) 220-230
  CrossrefPubMedGoogle Scholar
• 12 Nava S, Schreiber A, Domenighetti G. Noninvasive ventilation for patients with acute lung injury or acute respiratory distress syndrome. Respir Care 2011; 56 (10) 1583-1588
  CrossrefPubMedGoogle Scholar
• 13 Wysocki M, Tric L, Wolff MA, Millet H, Herman B. Noninvasive pressure support ventilation in patients with acute respiratory failure. A randomized comparison with conventional therapy. Chest 1995; 107 (3) 761-768
  CrossrefPubMedGoogle Scholar
• 14 Delclaux C, L'Her E, Alberti C , et al. Treatment of acute hypoxemic nonhypercapnic respiratory insufficiency with continuous positive airway pressure delivered by a face mask: A randomized controlled trial. JAMA 2000; 284 (18) 2352-2360
  CrossrefPubMedGoogle Scholar
• 15 Ferrer M, Esquinas A, Leon M, Gonzalez G, Alarcon A, Torres A. Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trial. Am J Respir Crit Care Med 2003; 168 (12) 1438-1444
  CrossrefPubMedGoogle Scholar
• 16 Gristina GR, Antonelli M, Conti G , et al; GiViTI (Italian Group for the Evaluation of Interventions in Intensive Care Medicine). Noninvasive versus invasive ventilation for acute respiratory failure in patients with hematologic malignancies: a 5-year multicenter observational survey. Crit Care Med 2011; 39 (10) 2232-2239
  CrossrefPubMedGoogle Scholar
• 17 Agarwal R, Aggarwal AN, Gupta D. Role of noninvasive ventilation in acute lung injury/acute respiratory distress syndrome: a proportion meta-analysis. Respir Care 2010; 55 (12) 1653-1660
  PubMedGoogle Scholar
• 18 Agarwal R, Handa A, Aggarwal AN, Gupta D, Behera D. Outcomes of noninvasive ventilation in acute hypoxemic respiratory failure in a respiratory intensive care unit in north India. Respir Care 2009; 54 (12) 1679-1687
  PubMedGoogle Scholar
• 19 Antonelli M, Conti G, Moro ML , et al. Predictors of failure of noninvasive positive pressure ventilation in patients with acute hypoxemic respiratory failure: a multi-center study. Intensive Care Med 2001; 27 (11) 1718-1728
  CrossrefPubMedGoogle Scholar
• 20 Antonelli M, Conti G, Rocco M , et al. A comparison of noninvasive positive-pressure ventilation and conventional mechanical ventilation in patients with acute respiratory failure. N Engl J Med 1998; 339 (7) 429-435
  CrossrefPubMedGoogle Scholar
• 21 Honrubia T, García López FJ, Franco N , et al. Noninvasive vs conventional mechanical ventilation in acute respiratory failure: a multicenter, randomized controlled trial. Chest 2005; 128 (6) 3916-3924
  CrossrefPubMedGoogle Scholar
• 22 Zhan Q, Sun B, Liang L , et al. Early use of noninvasive positive pressure ventilation for acute lung injury: a multicenter randomized controlled trial. Crit Care Med 2012; 40 (2) 455-460
  CrossrefPubMedGoogle Scholar
• 23 Ferguson ND, Fan E, Camporota L , et al. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med 2012; 38 (10) 1573-1582
  CrossrefPubMedGoogle Scholar
• 24 Meduri GU, Turner RE, Abou-Shala N, Wunderink R, Tolley E. Noninvasive positive pressure ventilation via face mask. First-line intervention in patients with acute hypercapnic and hypoxemic respiratory failure. Chest 1996; 109 (1) 179-193
  CrossrefPubMedGoogle Scholar
• 25 Antonelli M, Conti G, Esquinas A , et al. A multiple-center survey on the use in clinical practice of noninvasive ventilation as a first-line intervention for acute respiratory distress syndrome. Crit Care Med 2007; 35 (1) 18-25
  CrossrefPubMedGoogle Scholar
• 26 Domenighetti G, Gayer R, Gentilini R. Noninvasive pressure support ventilation in non-COPD patients with acute cardiogenic pulmonary edema and severe community-acquired pneumonia: acute effects and outcome. Intensive Care Med 2002; 28 (9) 1226-1232
  CrossrefPubMedGoogle Scholar
• 27 Jolliet P, Abajo B, Pasquina P, Chevrolet JC. Non-invasive pressure support ventilation in severe community-acquired pneumonia. Intensive Care Med 2001; 27 (5) 812-821
  CrossrefPubMedGoogle Scholar
• 28 Confalonieri M, Potena A, Carbone G, Porta RD, Tolley EA, Umberto Meduri G. Acute respiratory failure in patients with severe community-acquired pneumonia. A prospective randomized evaluation of noninvasive ventilation. Am J Respir Crit Care Med 1999; 160 (5 Pt 1) 1585-1591
  CrossrefPubMedGoogle Scholar
• 29 Pham T, Combes A, Rozé H , et al; REVA Research Network. Extracorporeal membrane oxygenation for pandemic influenza A(H1N1)-induced acute respiratory distress syndrome: a cohort study and propensity-matched analysis. Am J Respir Crit Care Med 2013; 187 (3) 276-285
  CrossrefPubMedGoogle Scholar
• 30 Nicolini A, Tonveronachi E, Navalesi P , et al. Effectiveness and predictors of success of noninvasive ventilation during H1N1 pandemics: a multicenter study. Minerva Anestesiol 2012; 78 (12) 1333-1340
  PubMedGoogle Scholar
• 31 Brink M, Hagberg L, Larsson A, Gedeborg R. Respiratory support during the influenza A (H1N1) pandemic flu in Sweden. Acta Anaesthesiol Scand 2012; 56 (8) 976-986
  CrossrefPubMedGoogle Scholar
• 32 Masclans JR, Pérez M, Almirall J , et al; H1N1 GTEI/SEMICYUC Investigators. Early non-invasive ventilation treatment for severe influenza pneumonia. Clin Microbiol Infect 2013; 19 (3) 249-256
  CrossrefPubMedGoogle Scholar
• 33 Timenetsky KT, Aquino SH, Saghabi C , et al. High success and low mortality rates with non-invasive ventilation in influenza A H1N1 patients in a tertiary hospital. BMC Res Notes 2011; 4: 375
  CrossrefPubMedGoogle Scholar
• 34 McCracken J. Should noninvasive ventilation be considered a high-risk procedure during an epidemic?. CMAJ 2009; 181 (10) 663-664
  CrossrefPubMedGoogle Scholar
• 35 Cammarota G, Olivieri C, Costa R , et al. Noninvasive ventilation through a helmet in postextubation hypoxemic patients: physiologic comparison between neurally adjusted ventilatory assist and pressure support ventilation. Intensive Care Med 2011; 37 (12) 1943-1950
  CrossrefPubMedGoogle Scholar
• 36 Vaschetto R, Turucz E, Dellapiazza F , et al. Noninvasive ventilation after early extubation in patients recovering from hypoxemic acute respiratory failure: a single-centre feasibility study. Intensive Care Med 2012; 38 (10) 1599-1606
  CrossrefPubMedGoogle Scholar
• 37 Laghi F, Fernandez R. Noninvasive ventilation for weaning in hypoxemic respiratory failure: not ready for prime time. Intensive Care Med 2012; 38 (10) 1583-1585
  CrossrefPubMedGoogle Scholar
• 38 Antonelli M, Conti G, Bufi M , et al. Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial. JAMA 2000; 283 (2) 235-241
  CrossrefPubMedGoogle Scholar
• 39 Azoulay E, Alberti C, Bornstain C , et al. Improved survival in cancer patients requiring mechanical ventilatory support: impact of noninvasive mechanical ventilatory support. Crit Care Med 2001; 29 (3) 519-525
  CrossrefPubMedGoogle Scholar
• 40 Confalonieri M, Calderini E, Terraciano S , et al. Noninvasive ventilation for treating acute respiratory failure in AIDS patients with Pneumocystis carinii pneumonia. Intensive Care Med 2002; 28 (9) 1233-1238
  CrossrefPubMedGoogle Scholar
• 41 Hilbert G, Gruson D, Vargas F , et al. Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med 2001; 344 (7) 481-487
  CrossrefPubMedGoogle Scholar
• 42 Squadrone V, Massaia M, Bruno B , et al. Early CPAP prevents evolution of acute lung injury in patients with hematologic malignancy. Intensive Care Med 2010; 36 (10) 1666-1674
  CrossrefPubMedGoogle Scholar
• 43 Truwit JD, Bernard GR. Noninvasive ventilation—don't push too hard. N Engl J Med 2004; 350 (24) 2512-2515
  CrossrefPubMedGoogle Scholar
• 44 Baillard C, Fosse JP, Sebbane M , et al. Noninvasive ventilation improves preoxygenation before intubation of hypoxic patients. Am J Respir Crit Care Med 2006; 174 (2) 171-177
  CrossrefPubMedGoogle Scholar
• 45 Cracco C, Fartoukh M, Prodanovic H , et al. Safety of performing fiberoptic bronchoscopy in critically ill hypoxemic patients with acute respiratory failure. Intensive Care Med 2013; 39 (1) 45-52
  CrossrefPubMedGoogle Scholar
• 46 Antonelli M, Conti G, Riccioni L, Meduri GU. Noninvasive positive-pressure ventilation via face mask during bronchoscopy with BAL in high-risk hypoxemic patients. Chest 1996; 110 (3) 724-728
  CrossrefPubMedGoogle Scholar
• 47 Antonelli M, Conti G, Rocco M , et al. Noninvasive positive-pressure ventilation vs. conventional oxygen supplementation in hypoxemic patients undergoing diagnostic bronchoscopy. Chest 2002; 121 (4) 1149-1154
  CrossrefPubMedGoogle Scholar
• 48 Clouzeau B, Bui HN, Guilhon E , et al. Fiberoptic bronchoscopy under noninvasive ventilation and propofol target-controlled infusion in hypoxemic patients. Intensive Care Med 2011; 37 (12) 1969-1975
  CrossrefPubMedGoogle Scholar
• 49 Maitre B, Jaber S, Maggiore SM , et al. Continuous positive airway pressure during fiberoptic bronchoscopy in hypoxemic patients. A randomized double-blind study using a new device. Am J Respir Crit Care Med 2000; 162 (3 Pt 1) 1063-1067
  CrossrefPubMedGoogle Scholar
• 50 Chanques G, Jaber S, Delay JM, Perrigault PF, Lefrant JY, Eledjam JJ. Phoning study about postoperative practice and application of non-invasive ventilation [in French]. Ann Fr Anesth Reanim 2003; 22 (10) 879-885
  CrossrefPubMedGoogle Scholar
• 51 Jaber S, Delay JM, Chanques G , et al. Outcomes of patients with acute respiratory failure after abdominal surgery treated with noninvasive positive pressure ventilation. Chest 2005; 128 (4) 2688-2695
  CrossrefPubMedGoogle Scholar
• 52 Jaber S, Michelet P, Chanques G. Role of non-invasive ventilation (NIV) in the perioperative period. Best Pract Res Clin Anaesthesiol 2010; 24 (2) 253-265
  PubMedGoogle Scholar
• 53 Pelosi P, Jaber S. Noninvasive respiratory support in the perioperative period. Curr Opin Anaesthesiol 2010; 23 (2) 233-238
  CrossrefPubMedGoogle Scholar
• 54 Squadrone V, Coha M, Cerutti E , et al; Piedmont Intensive Care Units Network (PICUN). Continuous positive airway pressure for treatment of postoperative hypoxemia: a randomized controlled trial. JAMA 2005; 293 (5) 589-595
  CrossrefPubMedGoogle Scholar
• 55 Aguiló R, Togores B, Pons S, Rubí M, Barbé F, Agustí AG. Noninvasive ventilatory support after lung resectional surgery. Chest 1997; 112 (1) 117-121
  CrossrefPubMedGoogle Scholar
• 56 Perrin C, Jullien V, Vénissac N , et al. Prophylactic use of noninvasive ventilation in patients undergoing lung resectional surgery. Respir Med 2007; 101 (7) 1572-1578
  CrossrefPubMedGoogle Scholar
• 57 Zarbock A, Mueller E, Netzer S, Gabriel A, Feindt P, Kindgen-Milles D. Prophylactic nasal continuous positive airway pressure following cardiac surgery protects from postoperative pulmonary complications: a prospective, randomized, controlled trial in 500 patients. Chest 2009; 135 (5) 1252-1259
  CrossrefPubMedGoogle Scholar
• 58 Kindgen-Milles D, Müller E, Buhl R , et al. Nasal-continuous positive airway pressure reduces pulmonary morbidity and length of hospital stay following thoracoabdominal aortic surgery. Chest 2005; 128 (2) 821-828
  CrossrefPubMedGoogle Scholar
• 59 Auriant I, Jallot A, Hervé P , et al. Noninvasive ventilation reduces mortality in acute respiratory failure following lung resection. Am J Respir Crit Care Med 2001; 164 (7) 1231-1235
  CrossrefPubMedGoogle Scholar
• 60 Michelet P, Blayac D, Jaber S. Case scenario: management of postesophagectomy respiratory failure with noninvasive ventilation. Anesthesiology 2010; 113 (2) 454-461
  CrossrefPubMedGoogle Scholar
• 61 Michelet P, D'Journo XB, Seinaye F, Forel JM, Papazian L, Thomas P. Non-invasive ventilation for treatment of postoperative respiratory failure after oesophagectomy. Br J Surg 2009; 96 (1) 54-60
  CrossrefPubMedGoogle Scholar
• 62 Wallet F, Schoeffler M, Reynaud M, Duperret S, Workineh S, Viale JP. Factors associated with noninvasive ventilation failure in postoperative acute respiratory insufficiency: an observational study. Eur J Anaesthesiol 2010; 27 (3) 270-274
  PubMedGoogle Scholar
• 63 Conti G, Cavaliere F, Costa R , et al. Noninvasive positive-pressure ventilation with different interfaces in patients with respiratory failure after abdominal surgery: a matched-control study. Respir Care 2007; 52 (11) 1463-1471
  PubMedGoogle Scholar
• 64 Hernandez G, Fernandez R, Lopez-Reina P , et al. Noninvasive ventilation reduces intubation in chest trauma-related hypoxemia: a randomized clinical trial. Chest 2010; 137 (1) 74-80
  CrossrefPubMedGoogle Scholar
• 65 Azoulay E, Kouatchet A, Jaber S , et al. Noninvasive mechanical ventilation in patients having declined tracheal intubation. Intensive Care Med 2013; 39 (2) 292-301
  CrossrefPubMedGoogle Scholar
• 66 Azoulay E, Kouatchet A, Jaber S , et al. Non-invasive ventilation for end-of-life oncology patients. Lancet Oncol 2013; 14 (6) e200-e201
  CrossrefPubMedGoogle Scholar
• 67 Schortgen F, Follin A, Piccari L , et al. Results of noninvasive ventilation in very old patients. Ann Intensive Care 2012; 2 (1) 5
  CrossrefPubMedGoogle Scholar
• 68 Bülow HH, Thorsager B. Non-invasive ventilation in do-not-intubate patients: five-year follow-up on a two-year prospective, consecutive cohort study. Acta Anaesthesiol Scand 2009; 53 (9) 1153-1157
  CrossrefPubMedGoogle Scholar
• 69 Nava S, Ferrer M, Esquinas A , et al. Palliative use of non-invasive ventilation in end-of-life patients with solid tumours: a randomised feasibility trial. Lancet Oncol 2013; 14 (3) 219-227
  CrossrefPubMedGoogle Scholar
• 70 Azoulay E, Demoule A, Jaber S , et al. Palliative noninvasive ventilation in patients with acute respiratory failure. Intensive Care Med 2011; 37 (8) 1250-1257
  CrossrefPubMedGoogle Scholar
• 71 Schettino G, Altobelli N, Kacmarek RM. Noninvasive positive pressure ventilation reverses acute respiratory failure in select “do-not-intubate” patients. Crit Care Med 2005; 33 (9) 1976-1982
  CrossrefPubMedGoogle Scholar
• 72 Antonelli M, Pennisi MA, Pelosi P , et al. Noninvasive positive pressure ventilation using a helmet in patients with acute exacerbation of chronic obstructive pulmonary disease: a feasibility study. Anesthesiology 2004; 100 (1) 16-24
  CrossrefPubMedGoogle Scholar
• 73 Chiumello D, Pelosi P, Carlesso E , et al. Noninvasive positive pressure ventilation delivered by helmet vs. standard face mask. Intensive Care Med 2003; 29 (10) 1671-1679
  CrossrefPubMedGoogle Scholar
• 74 Vargas F, Thille A, Lyazidi A, Campo FR, Brochard L. Helmet with specific settings versus facemask for noninvasive ventilation. Crit Care Med 2009; 37 (6) 1921-1928
  CrossrefPubMedGoogle Scholar
• 75 Dimassi S, Vargas F, Lyazidi A, Roche-Campo F, Dellamonica J, Brochard L. Intrapulmonary percussive ventilation superimposed on spontaneous breathing: a physiological study in patients at risk for extubation failure. Intensive Care Med 2011; 37 (8) 1269-1276
  CrossrefPubMedGoogle Scholar
• 76 Cuquemelle E, Pham T, Papon JF, Louis B, Danin PE, Brochard L. Heated and humidified high-flow oxygen therapy reduces discomfort during hypoxemic respiratory failure. Respir Care 2012; 57 (10) 1571-1577
  CrossrefPubMedGoogle Scholar
• 77 Díaz-Lobato S, Folgado MA, Chapa A, Mayoralas Alises S. Efficacy of high-flow oxygen by nasal cannula with active humidification in a patient with acute respiratory failure of neuromuscular origin. Respir Care 2013; 58 (12) e164-e167
  CrossrefPubMedGoogle Scholar
• 78 Peters SG, Holets SR, Gay PC. High-flow nasal cannula therapy in do-not-intubate patients with hypoxemic respiratory distress. Respir Care 2013; 58 (4) 597-600
  PubMedGoogle Scholar
• 79 Sztrymf B, Messika J, Bertrand F , et al. Beneficial effects of humidified high flow nasal oxygen in critical care patients: a prospective pilot study. Intensive Care Med 2011; 37 (11) 1780-1786
  CrossrefPubMedGoogle Scholar
• 80 Demoule A, Girou E, Richard JC, Taille S, Brochard L. Benefits and risks of success or failure of noninvasive ventilation. Intensive Care Med 2006; 32 (11) 1756-1765
  CrossrefPubMedGoogle Scholar