Original ArticlesA randomized controlled trial of a 3-year home exercise program in cystic fibrosis☆,☆☆
Section snippets
Patients
For this investigation, 72 mildly to moderately impaired patients with CF (FEV1 ≥40%), ranging in age from 7 to 19 years, were recruited at the CF clinic at The Hospital for Sick Children in Toronto. Although 162 patients met the eligibility criteria, not all were available to participate because of enrollment in other studies, a history of noncompliance with study protocols, or irregularity of visits to the clinic. Before commencement of the study, the protocol was approved by the Human
RESULTS
Of 72 patients with CF who entered this study, 4 (3 girls and 1 boy) dropped out of the exercise group (1 moved and 3 quit) before completion of year 1, and 3 patients (2 girls from the exercise group and 1 boy from the control group) withdrew before completion of year 2 (1 had poor health, 1 was incarcerated, and 1 was pregnant). Subsequently, one girl in the control group died before completion of year 3. Data for the 7 subjects who did not complete at least 2 years of follow-up in the study
DISCUSSION
A 3-year program of exercise therapy slowed the rate of decline in pulmonary function for a group of mildly to moderately impaired patients with CF. Rates of decline in the exercise group were less than those of the control group, which were similar to those previously reported in another sample of patients with comparable disease severity from the same CF population.24 In another randomized controlled trial35 in which patients were allocated to receive either ibuprofen or a placebo, rates of
Acknowledgements
This article was prepared with the assistance of Editorial Services, The Hospital for Sick Children, Toronto, Ontario, Canada.
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Physical activity and exercise training in cystic fibrosis [1]
2022, Paediatric Respiratory ReviewsRespiratory physiotherapy in pediatric practice
2022, Revue des Maladies RespiratoiresThe effectiveness of exercise interventions to increase physical activity in Cystic Fibrosis: A systematic review
2022, Journal of Cystic FibrosisCitation Excerpt :However, only two of these studies also had an associated significant increase in PA [46,48]. In a three-year intervention, FEV1 declined more slowly in the aerobic exercise group compared to the control group [46]. Selvadurai et al [48] found that FEV1 was significantly improved following an inpatient exercise intervention, however this was noted across both interventions (aerobic: 6.54%; resistance 10.09%) and within the control group (4.51%).
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Supported by a grant from the Canadian Cystic Fibrosis Foundation.
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Reprint requests: J. Joseph Reisman, MD, Paediatric Respiratory Medicine, The Hospital for Sick Children, 555 University Ave, Toronto ON M5G 1X8, Canada.