Plasma Cystatin C Concentration Reflects the Severity of Coronary Artery Disease in Patients Without Chronic Kidney Disease

Arihiro Kiyosue; Yasunobu Hirata; Jiro Ando; Hideo Fujita; Toshihiro Morita; Masao Takahashi; Daisuke Nagata; Takahide Kohro; Yasushi Imai; Ryozo Nagai

doi:10.1253/circj.CJ-10-0158

Renal Disease

Plasma Cystatin C Concentration Reflects the Severity of Coronary Artery Disease in Patients Without Chronic Kidney Disease

Arihiro Kiyosue, Yasunobu Hirata, Jiro Ando, Hideo Fujita, Toshihiro Morita, Masao Takahashi, Daisuke Nagata, Takahide Kohro, Yasushi Imai, Ryozo Nagai

Author information

Arihiro Kiyosue
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
Yasunobu Hirata
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
Jiro Ando
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
Hideo Fujita
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
Toshihiro Morita
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
Masao Takahashi
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
Daisuke Nagata
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
Takahide Kohro
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
Yasushi Imai
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
Ryozo Nagai
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

Keywords: Chronic kidney disease, Coronary artery disease, Glomerular filtration rate, Renal function

JOURNAL FREE ACCESS

2010 Volume 74 Issue 11 Pages 2441-2447

DOI https://doi.org/10.1253/circj.CJ-10-0158

View "Advance Publication" version (September 29, 2010).

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Abstract

Background: This study examines whether the serum concentration of cystatin C (Cys C) correlates with the severity of coronary artery disease (CAD) and whether it provides additional information on the risk for CAD in patients without chronic kidney disease (CKD) estimated by the creatinine-based glomerular filtration rate (GFR). Methods and Results: The relationship between serum Cys C and the severity of CAD in 526 patients was investigated. Based on GFR, patients were divided into those with and without CKD. The relationship of serum Cys C with the severity of CAD was examined. Serum Cys C was closely correlated with GFR in all cases and in CKD patients, but not in non-CKD patients. The average number of stenotic coronary arteries was significantly higher in the quartiles of higher concentration of Cys C as well as in those of GFR. In 348 patients (66%) the GFR was ≥60ml·min^-1·1.73m^-2. Those patients with increased Cys C (>0.90mg/L, 143 patients) had a significantly larger number of stenotic coronary arteries than those patients with normal Cys C. Conclusions: Among patients considered to be at low risk based on the estimated GFR using serum creatinine, those with high concentrations of Cys C could have severe CAD. Besides CKD, Cys C might serve as a marker of CAD severity. (Circ J 2010; 74: 2441-2447)

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