Chest
Original Research: InfectionsEtiology of Community-Acquired Pneumonia in Hospitalized Patients in Chile: The Increasing Prevalence of Respiratory Viruses Among Classic Pathogens
Section snippets
Materials and Methods
A prospective cohort study of consecutive patients admitted to the hospital with CAP was conducted between February 27, 2003, and April 15, 2005, at a 520-bed university-affiliated teaching hospital in Chile. The study received institutional review board approval, and informed consent was obtained from all patients. Subjects were included if they were not immunocompromised, were ≥ 16 years of age, and had radiographically confirmed pneumonia requiring hospitalization. CAP was defined as the
Patient Characteristics
One hundred seventy-six patients (91 men and 85 women; mean age, 65.8 ± 18.5 years; range, 17 to 101 years) were studied. The principal clinical characteristics and chest radiograph findings are summarized inTable 1. The mean duration of clinical symptoms before hospital admission was 7.1 ± 5.7 days. Thirty percent of patients had received an antibiotic prior to hospital admission, and 20% were admitted to the ICU.
Diagnostic Yield of Applied Techniques
The number of samples collected and their yield are summarized inTable 2. For
Discussion
This study is the first to document the relative importance of various pathogens in causing CAP in hospitalized patients in Chile, a developing country. The main results were as follows:S pneumoniaewas the most frequent pathogen found followed by respiratory viruses; viruses were more common in elderly patients, and were isolated mainly in the fall or winter; and viral CAP patients had significant mortality.
The etiology was found in 55% of cases, and this figure is similar to those from some
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This research was supported by a grant from Dirección de Investigación de la P. Universidad Católica de Chile (DIPUC 2003/10E) and by investigation grants from Sociedad Chilena de Enfermedades Respiratorias (2002 and 2004).
The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).