Chest
ORIGINAL RESEARCHCRITICAL CARE MEDICINENonpulmonary Organ Dysfunction and Its Impact on Outcome in Patients With Acute Respiratory Failure
Section snippets
Materials and Methods
We prospectively recorded demographic, clinical, laboratory, and therapeutic data from hospital admission to discharge on all adult patients (aged ≥ 15 years) with ARF managed at our RICU over a 5-year period. The study was approved by our hospital ethics committee. Data were registered on hospital admission and every 24 h thereafter, using the worst daily values for all variables of interest. Day 0 was defined as the interval from time of RICU admission to 8:00 am the next day; data from this
Results
Data from 711 RICU admissions (428 men [60.2%] and 283 women [39.8%]) were analyzed. More than half (53.7%) required respiratory support for either ARDS or acute exacerbation of bronchial asthma or COPD (Table 1). The overall hospital mortality rate was 33.9%, with highest rates for patients with ARDS (Table 1). Of these, 14 deaths occurred in wards after patients had been transferred out of the RICU. On initial evaluation, 475 patients (66.8%) had at least one nonpulmonary organ dysfunction,
Discussion
Organ dysfunction is a continuum, from normal organ function, through varying degrees of organ dysfunction, to severe organ failure, and alters over the duration of patient's ICU stay. While clinicians understand the need to describe and quantify organ dysfunction, there is no consensus on the exact modality to do so. The SOFA is one such widely used instrument that not only describes severity of organ dysfunction, but also provides an aggregate score as a measure of morbidity related to organ
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The authors have no conflicts of interest to disclose.