Chest
Original ResearchCritical Care MedicineTranscutaneous Pco2 Monitoring During Initiation of Noninvasive Ventilation
Section snippets
Materials and Methods
The study protocol was approved by the institutional review board for human studies at the Albert-Ludwigs University, Freiburg, Germany, and was performed in accordance with the ethical standards laid down in the Declaration of Helsinki. Informed written consent was obtained from all patients.
Results
Ten patients (4 female patients) completed the study protocol. The mean age was 68.2 ± 8.6 years, and the mean body mass index was 28.1 ± 9.6 kg/m2. Eight patients had COPD, one patient had unclassified interstitial lung disease, and one patient had obesity hypoventilation syndrome.
Ventilator settings and measurements of gas exchange following the initiation of NPPV are shown in Table 1. The mean flow rate of supplemental oxygen was 3.5 ± 3.1 L/min during the whole study period. The mean
Discussion
In the present study, patients with acute deterioration of chronic HRF were established receiving NPPV therapy in a general respiratory ward. In this situation, NPPV has been shown to be highly effective by decreasing Paco2 by a mean of 13 mm Hg during 4 h of ventilation. The present study has shown that this trend of declining Paco2 levels is reliably assessed by the noninvasive measurement of Ptcco2.
There have been some previous studies61112131415 that have addressed the usefulness of Ptcco2
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The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
The study was supported by SentTec AG, Therwil, Switzerland, and BREAS Medical AB, Mölnlycke, Sweden.