Chest
Original ResearchSleep MedicineLong-term Effect of Continuous Positive Airway Pressure on BP in Patients With Hypertension and Sleep Apnea
Section snippets
Design and Patients
A prospective, long-term follow-up trial of consecutive patients referred to the Sleep Disorders Unit of the Valme University Hospital (Seville, Spain) between January and September 2003 with a suspected diagnosis of OSA was conducted. Patients were considered for inclusion if they were between 30 and 70 years of age with an apnea-hypopnea index (AHI) ≥ 10/h in conventional polysomnography, and a previous diagnosis of hypertension and receiving treatment with at least one drug for at least 3
Results
Seventy patients fulfilled the inclusion criteria, but 4 patients declined to take part in the study (2 patients lived too far away, and 2 patients refused treatment with CPAP). The remaining 66 patients began the study. Seven patients were unavailable for follow-up (three patients could not be contacted, and four patients refused follow-up visits), and four patients withdrew CPAP before the end point and were thus excluded. Finally, 55 patients completed the study. The study sample was similar
Discussion
The results of this study show that long-term CPAP treatment increased the proportion of patients who regained the normal circadian dipping pattern and showed significant reductions in diastolic BP, but only a modest effect on the rest of ABPM parameters in patients with OSA and hypertension undergoing antihypertensive treatment. Most importantly, in the subgroups of patients with good compliance or poorly controlled hypertension at entry, CPAP was especially effective in causing significant
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This study was performed without subsidy or financial support.
The authors have no conflicts of interest to disclose.