Chest
Original ResearchSmoking and Skeletal MusclesPeripheral Muscle Alterations in Non-COPD Smokers
Section snippets
Study Subjects
The study group consisted of 14 current smokers subjects (30 ± 10 pack-years), with normal spirometry results who were recruited from the smoking cessation clinic of the Hospital Universitario de Caracas. Twenty healthy sedentary nonsmoking subjects served as control subjects. The committee on human research approved the study, and all subjects signed the informed consent.
A non-COPD smoker was defined as a postbronchodilator FEV1/FVC ratio > 0.7, and a smoking history > 20 pack-years. Smokers
Results
The clinical characteristics and spirometric data of the non-COPD smokers and controls subjects are detailed in Table 1. There were no differences in age, weight, height, body mass index, and pulmonary function between the groups.
The smokers and control subjects fiber type distribution, mean CSA of the fibers, CSA of the different fiber types, capillarity measured as capillaries per square millimeter, capillaries per fiber, and the number of capillary contacts with the different fiber types are
Discussion
There were several important findings in this study of non-COPD smoker skeletal muscle. Smoker subjects had reduced CSA of type I fibers and a similar trend in type IIa fibers compared with control subjects. LDH levels and the percentage of fibers with low oxidative and high glycolytic capacity were increased in smokers. Muscular eNOS and nNOS concentrations were decreased in smokers, and there was no evidence supporting the presence of local inflammation in the skeletal muscle of these
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Grant support was provided by Fondo Nacional de Ciencia, Tecnología e Innovación, S1-2005000149, G-2005000389, Consejo de Desarrollo Científico y Humanístico, Universidad Central de Venezuela, 09.33.4367.2005.
The authors have no conflicts of interest to disclose.