Chest
Original ResearchCritical Care MedicineSelf-Reported Symptoms of Depression and Memory Dysfunction in Survivors of ARDS
Section snippets
Patients
The patients in this study had participated in a previously reported prospective cohort study of ARDS survivors enrolled from ICUs at four University of Toronto teaching hospital, between May 1998 and May 2001.9, 11, 18 Eligible patients were at least 16 years old and had a Pao2/inspired fraction of oxygen ratio of 200 or less while receiving mechanical ventilation with a positive end-expiratory pressure of at least 5 cm H2O, airspace changes in all four quadrants on chest radiography, and an
Study Participants
We enrolled 109 ARDS survivors in the cohort, of whom 13 had died and 14 had withdrawn from the study at the time of questionnaire mailing. We sent questionnaires to all remaining 82 patients in the cohort; they were returned at a median of 22 (IQR 12 to 29; range 6 to 48) months post-ICU discharge (Fig 1). Sixty-eight (83%) patients returned the BDI-II and 71 (87%) patients returned the MAC-S questionnaires. Responders were similar to nonresponders (Table 1); they were young (42 [IQR 35 to 56]
Discussion
In this study, critically ill patients who survived an episode of ARDS completed validated instruments assessing self-reported symptoms of depression and memory dysfunction between 6 and 48 months after ICU discharge. These patients had high initial illness severity and no documented psychiatric comorbidity. Our main findings were a high prevalence (41%) of moderate-severe depression symptoms and a lower prevalence (8 to 20%, depending on the definition used) of self-reported memory deficits.
Acknowledgment
We thank Fatma al-Saidi for major contributions to data collection and early analyses.
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Cited by (0)
This study was supported by Physicians' Services Incorporated, Ontario Thoracic Society, and Canadian Intensive Care Foundation.
All authors declare that no financial or other potential conflicts of interest exist. Dr. Adhikari had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).