Chest
Volume 138, Issue 2, August 2010, Pages 458-459
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Correspondence
Comparison Among Different Methods on Measurement of Total Lung Capacity in COPD

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To the Editor

I read the article by O'Donnell and coworkers1 recently published in CHEST (May 2010). Their conclusions about the accuracy of two functional methods (plethysmographic and dilutional) to measure lung volumes (in this case, total lung capacity [TLC]) in patients with severe airway obstruction are based on the assumption that CT scan is the reference method.

Several doubts exist that CT scan may be adopted as a gold standard for measuring TLC, especially in the above-mentioned study, for the

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