Chest
Clinical InvestigationsPhotodynamic Therapy in the Management of Early Superficial Squamous Cell Carcinoma as an Alternative to Surgical Resection
Section snippets
Selection of Patients
All patients in our study had biopsy specimen-proven squamous cell carcinoma involving the tracheobronchial tree. Conventional chest roentgenograms were obtained for all patients and computed tomography of the chest was performed for most of them. These studies showed no evidence of cancer spread. Each patient was thought to be a surgical candidate, as determined by pulmonary function testing and general cardiac assessment. Informed consent was obtained from each patient prior to therapy.
Hematoporphyrin Derivative
We
RESULTS
Thirteen patients (14 cancers) were treated with HpD-PT and the results were analyzed (Table 1). The results were categorized according to the therapeutic response after HpD-PT, the subsequent behavior of the tumor, long-term results, and the status of each patient as of October 1991.
DISCUSSION
Photodynamic therapy has been used for management of bronchogenic carcinoma at our institution for the last ten years. Initially, the treatment modality was confined to patients who were thought not to be surgical candidates because of underlying cardiopulmonary dysfunction. The effectiveness of HpD-PT is known to be limited because the maximal therapeutic depth of penetration by activating light is no more than 2 cm. Therefore, we believe that for the management of bronchogenic carcinoma, the
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Manuscript received December 3; revision accepted February 10.