Chest
Clinical Investigations: COPDNasal Intermittent Positive Pressure Ventilation: Long-term Follow-up in Patients With Severe Chronic Respiratory Insufficiency
Section snippets
Methods
Subjects were 276 patients diagnosed as having idiopathic kyphoscoliosis, posttuberculosis sequelae, Duchenne-type muscular dystrophy, COPD, and bronchiectasis. All were treated with NIPPV between 1985 and 1990 by four French teams in an integrated system consisting of hospital units and home care associations. Data were obtained by the teams and compiled by one of the researchers (P.L.). The sample included all patients treated with NIPPV during this time, with the exception of 94 patients.
Results
Table 1 presents a profile of the 276 patients. Pulmonary function tests reflected severe restrictive or obstructive disease. Mean ABG values indicated severe hypoxemia and hypercarbia for all groups, with the exception of those diagnosed as having Duchenne-type muscular dystrophy. A substantial number of patients with COPD (88 percent), bronchiectasis (84 percent), kyphoscoliosis (54 percent), and posttuberculosis sequelae (64 percent) were receiving long-term oxygen therapy.
Discussion
Since its introduction in 1984, NIPPV has become an established method of treatment for patients with restrictive chest wall disorders and neuromuscular diseases. In addition, NIPPV may have the potential to benefit other patients, such as those with COPD or bronchiectasis. Few studies have evaluated this possibility in patients in COPD and no studies were identified that evaluated effects of NIPPV in patients with bronchiectasis. Therefore, we initiated this study.
Our results demonstrate that
ACKNOWLEDGEMENTS
The authors wish to acknowledge the assistance of the home care nurses, respiratory therapists, and technicians who assisted with patient care and data collection during this study and thank Leslie A. Hoffman, R.N., Ph.D., for invaluable aid in writing of this manuscript.
References (26)
Intermittent volume cycled mechanical ventilation via nasal mask in patients with respiratory failure due to COPD
Chest
(1991)- et al.
Noninvasive face mask ventilation in patients with acute respiratory failure
Chest
(1989) - et al.
Management of chronic alveolar hypoventilation by nasal ventilation
Chest
(1990) - et al.
Noninvasive ventilatory support during sleep improves respiratory failure in kyphoscoliosis
Chest
(1988) - et al.
Influence of noninvasive positive pressure ventilation on inspiratory muscles
Chest
(1991) - et al.
Intermittent positive pressure ventilation via nasal access in the management of respiratory insufficiency
Chest
(1987) - et al.
Ventilatory muscle support in respiratory failure with nasal positive pressure ventilation
Chest
(1990) - et al.
Efficacy of positive vs negative pressure in unloading the respiratory muscles
Chest
(1990) Traiment de l'insuffisance respiratoire chronique dans les dystrophies musculaires
Management of the wheel chair muscular dystrophy patient: prevention of death [abstract]
Fourth International Congress on Neuromuscular Diseases
(1986)
Non-invasive and domiciliary ventilation; positive pressure techniques
Thorax
The successful reversal of hypoxia using nasal intermittent positive pressure ventilation plus added oxygen in respiratory failure due to acute exacerbations of chronic airways disease [abstract]
Am Rev Respir Dis
Acute failure of chronic respiratory insufficiency treated by nasal mechanical ventilation [abstract]
Am Rev Respir Dis
Cited by (440)
Mechanical Ventilation: Negative to Positive and Back Again
2023, Critical Care ClinicsDomiciliary noninvasive ventilation for chronic respiratory diseases
2022, Medical Journal Armed Forces IndiaImpact of Interface Type on Noninvasive Ventilation Efficacy in Patients With Neuromuscular Disease: A Randomized Cross-Over Trial
2021, Archivos de BronconeumologiaDyspnea
2021, Encyclopedia of Respiratory Medicine, Second EditionIntroduction and Terminology of Sleep Disordered Breathing
2021, Encyclopedia of Respiratory Medicine, Second Edition