Chest
Original ResearchAsthmaThe Relationship of Asthma Impairment Determined by Psychometric Tools to Future Asthma Exacerbations
Section snippets
Materials and Methods
This study was approved by the Kaiser Permanente Southern California Institutional Review Board (Study number 4940). Informed consent was waived by the institutional review board; completion of the survey was taken as consent to participate. The study patients (aged 18-56 years with Healthcare Effectiveness Data and Information Set-defined persistent asthma in 2006) have been previously described in a report focusing on persistent asthma.15
Patients
The baseline (November 2007) survey was returned by 2,751 patients (20.1%), of whom 2,680 (97.4%) had complete results for all three tools and make up the study cohort for this report. The 2,680 current study patients were primarily female, well-educated nonsmokers on regular asthma controller therapy, and a majority were white (Table 1). More than one-third of the patients reported unscheduled asthma visits in the prior 12 months, and nearly 40% required oral corticosteroids for asthma
Discussion
Asthma impairment (including asthma control and asthma-specific quality of life) and risk of asthma exacerbations are considered two separate domains, but the current study confirms that these two domains are related to each other. Patients who suffered asthma exacerbations during 12 months of follow-up had significantly greater baseline asthma impairment (as assessed by each of the three tested tools: ACT, mAQLQ, and AIS-6) compared with patients who did not experience exacerbations during the
Acknowledgments
Author contributions: Dr Schatz: contributed to study design, data analysis, data interpretation, and manuscript preparation, and is the guarantor of the manuscript.
Dr Zeiger: contributed to study design, data interpretation, and manuscript preparation.
Dr Yang: contributed to data acquisition, data analysis, and manuscript review.
Ms Chen: contributed to study design, data acquisition, data interpretation, and manuscript review.
Dr Crawford: contributed to study design, data interpretation, and
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Funding/Support: This study was funded by a research grant from Merck & Co, Inc.
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