Chest
Clinical Investigations: NebulizersAerosol Delivery During Continuous Nebulization
Section snippets
Selection of Nebulizers
Because our group has previously reported that disposable plastic nebulizers may vary significantly in output within the same manufacturing lot,10,11 we used the “standing cloud” technique12, 13, 14 to pretest 12 HEART, six AeroTech II (No. CA-1200A; CIS-US; Bedford, Mass), and six PowerMist nebulizers (No. 3759; Hospitak; Lindenhurst, NY), all from the same manufacturer’s lot, to determine their comparability and to enable selection of similar nebulizers for subsequent experiments. The
Output Studies (Albuterol Delivery)
The AeroTech II and PowerMist nebulizers nebulized a 3-mL charge in a mean time of 10 min. The HEART nebulizers with a 120-mL charge ran dry in a mean of 240 min in the adult breathing pattern and 270 min in the pediatric breathing pattern.
Table 1 summarizes the measured data. The two SVNs, AeroTech II and PowerMist, both emptied in 10 min and delivered an inhaled mass of 0.86 mg and 0.62 mg, respectively, for the adult breathing pattern. Significant differences were noted for the pediatric
DISCUSSION
Our studies, as summarized in Table 1 and Figure 4, demonstrate that, under conditions simulating patient therapy with both adult and pediatric breathing patterns, a wide range in aerosolized albuterol can be inhaled over time with different nebulizers. But, with some attention paid to the drug concentration in the nebulizer, similar quantities will be inhaled using all devices. Further, as shown in Figure 4 for the adult breathing pattern, the HEART CN approaches a typical SVN at its highest
ACKNOWLEDGMENT
Lorraine Morra, BS, performed the albuterol assay.
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Supported by University Hospital Operational Grant 371318. The authors have no financial interest in any of the products or companies mentioned herein.