Chest
Clinical Investigations: COPDRight and Left Ventricular Dysfunction in Patients With Severe Pulmonary Disease
Section snippets
Patients
The files of 464 patients with end-stage lung disease who had been evaluated for lung transplantation at Barnes-Jewish Hospital between January 1993 and December 1995, were reviewed. The medical records of all referrals were screened before an on-site evaluation, and standard guidelines were used to identify possible candidates for transplantation.10, 11, 12 Patients with a history of significant coronary artery disease, myocardial infarction, cardiomyopathy, or valvular disease were excluded
Clinical Variables
The study included 434 patients, 237 women and 197 men, with a mean age of 45.7±11.6 years (Table 1). The most common diagnosis was COPD; the other four disease groups were similar in size. Not unexpectedly, the characteristics were somewhat different among the five diagnostic groups. Patients with CF were younger, had a lower mean body weight, and had a higher mean hemoglobin concentration than the other groups. Patients with COPD were the oldest, and patients with IPF were heavier. Female
Discussion
The cardiovascular status of patients with advanced lung disease has not been extensively studied, and the relationship between right ventricular and left ventricular function in this setting remains uncertain. In this study, the prevalence of right and left ventricular dysfunction was determined in a prescreened population with severe pulmonary disease who had been evaluated for lung transplantation. The diseases included the common parenchymal and airway diseases (A1E, COPD, CF, and IPF) and
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