Chest
Clinical InvestigationsExerciseReproducibility of Maximal Exercise Ergometer Testing in Patients With Cystic Fibrosis
Section snippets
Patients
Characteristics of our study population are outlined in Table 1. The subjects (six men and three women) were recruited from outpatients in the National Adult Cystic Fibrosis Unit, St. Vincent's University Hospital. All subjects had clinical, radiologic, and physiologic evidence of CF-related lung disease, and they all had CF diagnoses based on clinical features, abnormal sweat test (sweat sodium and chloride > 60 mmol/L), and genotyping. All subjects were clinically stable for a period of 2
Results
All subjects completed each exercise test without any complications, and no exercise test was terminated by the physician.
Discussion
As in previous studies1234567 of exercise in patients with CF, our patients showed reduced exercise tolerance with reduced maximal workload and o2max. Our patients had increased ventilatory requirements with a high ventilation (e), an elevated ventilatory equivalent for oxygen (e/o2) and an increased e/MVV at end exercise. Two patients reached their predicted maximum HR. The three patients with the lowest FEV1 showed significant oxygen desaturation during exercise.
We looked at the
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Supported by the Cystic Fibrosis Research Trust and a researchfellowship grant from the Irish Lung Association (E.F.M.).