Chest
BronchoscopyEarly Detection of Lung Cancer With Laser-Induced Fluorescence Endoscopy and Spectrofluorometry
Section snippets
Subjects
A total of 65 subjects underwent bronchoscopy with LIFE. Weperformed a radiographic examination of heavy smokers identified asbelonging to a high-risk group during mass screening for lung cancer, made available to individuals aged ≥ 40 years residing in any ofseven cities in Osaka Prefecture, and examined sputum specimenscytologically. Results of the sputum examination called for furtherstudy of 26 patients, who were enrolled in our trial of bronchoscopywith LIFE. Another 21 patients presented
Results
The mean cigarette index (packs of cigarettes per day times yearsat that consumption rate) for the 63 smokers was 55 packs (range, 5 to140 packs), and two patients were nonsmokers. In all, 216 sitesunderwent biopsy. The histopathologic diagnoses of the specimens wereas follows. Forty-six findings were normal. Of the 142 nonmalignantlesions, 28 were of inflammation or hyperplasia, 49 were of milddysplasia, 44 were of moderate dysplasia, and 21 were of severedysplasia (precancerous). Of the 23
Discussion
The combination of conventional bronchoscopy and LIFE can improvedetection of endobronchial lesions.1314 We found thesensitivity in detection of severe dysplasia and cancer, including CIS,by this combination to be 29 percentage points higher (improvement byslightly less than 50%) than by conventional bronchoscopy alone. Thespecificity with this combination was lower by about 7 percentagepoints. We concluded that all sites considered suspicious by eithermethod should be examined.
The extent of
References (17)
- et al.
Photodynamic therapy in lung cancer: a review
J Photochem Photobiol B
(1996) Strategies for treatment of occult carcinomas of the endobronchus
Chest
(1997)- et al.
Fluorescence bronchoscopy for detection of lung cancer
Chest
(1979) - et al.
Early detection of lung cancer by means of hematoporphyrin derivative fluorescence and laser photoradiation
Clin Chest Med
(1985) - et al.
Inhalation of 5-aminolevulinic acid: a new technique for fluorescence detection of early stage lung cancer
J Photochem Photobiol B
(1996) - et al.
Detection of dysplasia and carcinoma in situ with a lung imaging fluorescence endoscope device
J Thorac Cardiovasc Surg
(1993) - et al.
Assessment of usefulness of endobronchial ultrasonography in determination of depth of tracheobronchial tumor invasion
Chest
(1999) - et al.
A prospective phase II study on photodynamic therapy with photofrin II for centrally located early-stage lung cancer
J Clin Oncol
(1993)
Cited by (113)
Application of modulated optical excitation in the investigation and cure of diseases
2022, Photoacoustic and Photothermal Spectroscopy: Principles and ApplicationsLaser induced autofluorescence lifetime to identify larynx squamous cell carcinoma: Short series ex vivo study
2020, Journal of Photochemistry and Photobiology B: BiologyCitation Excerpt :If compared with immunohistochemistry (IHC), LIAF has advantages with respect to standard used methods in hospitals' laboratories to early detect/diagnose cancer tissues or cells. This is in line with other reports about using LIAF for detection of malignant tissues in lung [15,16] or brain [5,6,17–19] and it is based on the fact that autofluorescence is collected from emission at molecular level, giving consequently information about the molecular content of the samples on which even cell systems are organized. It has also the specificity that the inspected tissues are not impregnated with external fluorophores which may vitiate the measurements' results.
Cancer of the Lung: Non-Small Cell Lung Cancer and Small Cell Lung Cancer
2019, Abeloff’s Clinical OncologyCancer of the Lung: Non-Small Cell Lung Cancer and Small Cell Lung Cancer
2013, Abeloff's Clinical Oncology: Fifth EditionEarly Lung Cancer. Methods for Detection.
2013, Clinics in Chest MedicineCitation Excerpt :The composite image displayed depicts normal epithelium as light green; areas of abundant blood flow, seen not only in malignant epithelium but also in areas of chronic benign inflammation, as dark green; and malignant tissue as a magenta color (Fig. 1).17 Multiple studies demonstrated that AFB improves detection of preinvasive central airway lesions and, when combined with WLB, also of squamous dysplasia, CIS, and early lung carcinoma.11,14–29 A recent meta-analysis of 21 studies comparing WLB used with AFB versus WLB alone in the diagnosis of intraepithelial neoplasia and invasive lung cancer involving 3266 patients reported a pooled relative sensitivity of 2.04 (95% confidence interval [CI] 1.72–2.42) on a per-lesion basis in favor of a combined AFB and WLB approach.18