Chest
Original ResearchCOPDCardiovascular Comorbidity in COPD: Systematic Literature Review
Section snippets
Data Sources and Searches
An electronic literature search was conducted via PubMed (which comprises citations from MEDLINE, life science journals, and online books) for observational studies published between January 1990 and March 2012 reporting on CVD in patients with COPD or vice versa. Key terms used included medical subject headings and free texts related to CVD and its types (ie, coronary artery disease, myocardial infarction, heart failure, arrhythmia, and hypertension), and to COPD (specifically “Pulmonary
Results
In total, 25 studies were included in the current analysis; 22 studies provided an estimate for CVD risk in COPD, whereas four studies provided estimates of COPD risk in CVD (Table 1). Twelve studies used a cohort design, seven studies used nested case-control approach, and eight studies were cross-sectional. In the prospective studies, the duration of follow-up ranged from 1 to 27 years. The average age of participants ranged between 55 and 78 years. The percentage of male patients in the
Discussion
In this study, we systematically reviewed the literature to estimate the risk of CVD overall and partitioned into more specific disease types (CHF, CHD, arrhythmias, stroke, arterial hypertension, and PAD) in patients with COPD. To our knowledge, it provides the most comprehensive and systematic review of available information on the topic to date. Main results support that COPD is associated with an increased risk of CVD, with the risk of CVD increasing with the severity of airflow limitation
Acknowledgments
Authors contributions: Dr Müllerova had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Dr Müllerova: contributed to the literature search, creating the tables, and writing the manuscript and served as principle author.
Dr Agusti: contributed to review of the study proposal and the interim results and writing the manuscript.
Dr Erqou: contributed to the literature search, creating the initial review output,
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Funding/Support: This study was sponsored by GlaxoSmithKline plc [study code WEUSKOP4140].
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