Chest
Clinical InvestigationsCYSTIC FIBROSISLongitudinal Determinants of Peak Aerobic Performance in Children With Cystic Fibrosis
Section snippets
Subjects
Measurement of nutritional status, lung function, and exercise performance is part of the annual medical check-up of the Cystic Fibrosis Center of the Wilhelmina Children's Hospital and University Medical Center at Utrecht. Patients who met the following criteria were approached for the study: age between 4 years and 18 years; stable clinical condition, ie, no need for oral or IV antibiotic treatment in 3 months prior to testing; and ability to perform the tests. One hundred sixty-three
Results
Eight of the 79 children were excluded from the analysis because they did not fulfill the criteria for a maximum exercise test. Six children reached the age of 12 years during the study period and therefore changed from treadmill to cycle ergometer. Several studies202122 have shown higher o2peak on a treadmill compared to a cycle ergometer. Consecutive annual changes in o2peak could be the result of different exercise modes, and therefore these six children were also excluded.
Table 1 summarizes
Discussion
We longitudinally studied the effect of changes in FFM and lung function on peak aerobic capacity in children with CF. Our longitudinal data indicate that changes of peak aerobic capacity in children with CF can be ascribed, to a great extent, to changes in lung function. The additional effect of changes in FFM may explain an additional 9% of the variance of changes in o2peak.
The results of this longitudinal study are in agreement with results from cross-sectional sectional studies showing that
References (40)
- et al.
Effects of nutritional status on exercise performance in advanced cystic fibrosis
Chest
(1986) - et al.
Long-term change in exercise capacity, body mass, and pulmonary function in adults with cystic fibrosis
Chest
(1997) - et al.
Body composition in children: proposal for a method for calculating body fat percentage from body density or skin-fold measurements
Am J Clin Nutr
(1989) - et al.
Maximal oxygen intake and normographic assessment of functional aerobic impairment in cardiovascular disease
Am Heart J
(1973) - et al.
Lymphocyte glutathione levels in children with cystic fibrosis
Chest
(1999) - et al.
The quality of well-being in cystic fibrosis
Chest
(1989) - et al.
Exercise conditioning and cardiopulmonary fitness in cystic fibrosis
Chest
(1981) - et al.
A randomized controlled trial of a 3-year home exercise program in cystic fibrosis
J Pediatr
(2000) - et al.
The prognostic value of exercise testing in patients with cystic fibrosis
N Engl J Med
(1992) - et al.
Relative underweight in cystic fibrosis and its prognostic value
Acta Paediatr Scand
(1978)
Analysis of factors limiting maximal exercise performance in cystic fibrosis
Clin Sci
The role of nutritional status, airway obstruction, hypoxia, and abnormalities in serum lipid composition in limiting exercise tolerance in children with cystic fibrosis
Acta Paediatr Scand
Maximal work capacity in relation to nutritional status in children with cystic fibrosis
Eur Respir J
Factors limiting anaerobic performance in adolescent males with cystic fibrosis
Med Sci Sports Exerc
Muscle mass as a factor limiting physical work
J Appl Physiol
Body composition and maximal exercise performance in children
Hum Biol
Exercise testing in children
Pediatr Pulmonol
Role of exercise in the evaluation and management of pulmonary disease in children and youth
Med Sci Sports Exerc
Exercise and cystic fibrosis
J R Soc Med
Lung function in children and adolescents: methods, reference values
Cited by (74)
Factors predicting 6-min walking test indexes in adults with cystic fibrosis
2022, Science and SportsCitation Excerpt :Albumin is used as a nutritional parameter for evaluating CF, and albumin levels have been linked to exercise capacity in other respiratory diseases [27]; however, previous CF studies have not examined the impact of albumin levels on exercise capacity. Other nutritional parameters, such as fat-free mass and arm muscle area, have been shown to be determinants of peak aerobic and anaerobic performance [28,29]. Albumin levels might therefore also be expected to affect these patients’ exercise capacity.
Exercise and Lung Function in Child Health and Disease
2019, Kendig's Disorders of the Respiratory Tract in ChildrenRelationship between lung function and Modified Shuttle Test performance in adult patients with cystic fibrosis: A cross-sectional, retrospective study
2016, Physiotherapy (United Kingdom)Citation Excerpt :A validation study by Bradley et al. showed that there is a strong relationship between MST performance and peak oxygen uptake in adults with CF, thus providing a good alternative for a formal laboratory exercise test with analysis of expired air [4]. Several studies have shown that peak oxygen uptake in patients with CF is associated with lung function [11–15]. It is generally assumed that the pulmonary system has an over-capacity of approximately 30% [16], and that small impairments may not lead to functional loss.
Evaluation of factors related to bone disease in Polish children and adolescents with cystic fibrosis
2015, Advances in Medical SciencesMechanisms of Exercise Limitation in Cystic Fibrosis: A Literature Update of Involved Mechanisms
2015, Diet and Exercise in Cystic Fibrosis