Chest
Laboratory and Animal InvestigationsSide Effects of Endotracheal Suction in Pressure- and Volume-Controlled Ventilation
Section snippets
Materials and Methods
Twelve healthy anesthetized pigs of mixed breed (Hampshire, Yorkshire, and Swedish native breed) with a body weight ranging from 25 to 35 kg were investigated. The experimental protocol was examined and approved by the local Ethics Committee for Animal Experiments, Uppsala, Sweden. The study was performed in accordance with the recommendations of the Swedish National Board for Laboratory Animals.
Effect of Suction During PCV and VCV Using a 14F OSS
In PCV 1 min after suction, MPAP (p = 0.009) and venous admixture (p < 0.001) were increased, and Pao2 (p < 0.001), Vt (p < 0.001), and Crs (p < 0.001) were decreased. After 30 min, these changes were still significant; in addition, Paco2 had increased (p < 0.001). In VCV 1 min after suction, MPAP (p = 0.004), venous admixture (p = 0.001), and Pplat (p < 0.001) were increased, and Pao2 (p < 0.001) and Crs (p < 0.001) were decreased. Thirty minutes after suction, these variables had returned to
Discussion
We have shown that gas exchange and lung mechanics were more negatively affected by endotracheal suction in PCV than in VCV. Most of the negative effects of suction remained after 30 min in PCV, but this was not the case when VCV was used. One possible explanation is that in VCV, where the volume of each breath is the same, there is a small recruitment with each successive breath. However, in VCV, the changes in both Crs and Pplat remained 30 min after suction; this may indicate partial lung
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Cited by (0)
Financial support was provided by the Swedish Heart-Lung Fund, local funding at Uppsala University, and Datex-Ohmeda.