Chest
Selected ReportsTracheobronchial Adenoid Cystic Carcinoma: A Clinicopathologic Study of 14 cases
Section snippets
Case Selection and Histopathologic Review
All cases with a diagnosis of ACC in the tracheobronchial tree were retrospectively identified from the surgical pathology file during the period from 1992 to 2001 at the University of California San Diego Medical Center. All patients in the present study were treated at our Pulmonary Special Procedures Unit, which specializes in treating obstructive airway diseases with Nd-YAG laser photoresection via rigid bronchoscopy. Two pathologists (EA and ESY) examined all the hematoxylin-eosin-stained
Clinical Features
The clinical characteristics of each patient are summarized in Table 1. Five patients (35.7%) were men and 9 (64.3%) were women, with a presenting age at diagnosis ranging from 29 to 53 years (average age, 44 years). Five patients (35.7%) were smokers (average smoking history, 28.5 pack-years), 8 patients (57.1%) were nonsmokers, and the smoking history was unknown in 1 case. Major symptoms at the time of presentation included cough in 8 patients (57.1%), dyspnea in 10 patients (71.4%), and
Discussion
We report the clinicopathologic features of 14 ACC cases occurring in the tracheobronchial tree. In the past 20 years, the use of lasers for treating endobronchial disease has been tested and accepted as an important therapeutic modality for obstructive endobronchial or tracheal lesions.26 Although the primary role of laser resection in oncology patients is a palliative one, this technique may allow a prolonged survival when combined with other therapies.27 Most of our patients underwent
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Drs. Albers and Lawrie contributed equally to the study.