Chest
Clinical InvestigationsImprovements in Symptom-Limited Exercise Performance Over 8 h With Once-Daily Tiotropium in Patients With COPD
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Study Subjects
Patients with a clinical diagnosis of COPD based on American Thoracic Society criteria15 were eligible for the trial (Boehringer Ingelheim 205.223) if they fulfilled the following criteria: age 40 to 75 years, cigarette smoking > 10 pack-years, FEV1 ≤ 65% predicted, and functional residual capacity (FRC) measured by body plethysmography ≥ 120% predicted. Patients with a history of asthma, allergic rhinitis, or atopy were not eligible for the trial. Also, patients with any recognized
References (28)
- et al.
Emerging concepts in the evaluation of ventilatory limitation during exercise: the exercise tidal flow-volume loop
Chest
(1999) - et al.
A systematic review of the effects of bronchodilators on exercise capacity in patients with COPD
Chest
(2002) - et al.
Symptom intensity and subjective limitation to exercise in patients with cardiorespiratory disorders
Chest
(1996) - et al.
A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol
Chest
(2002) - et al.
ATS/ERS Task Force Committee Members. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper
Eur Respir J
(2004) - et al.
Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease
Can Respir J
(2003) International classification of impairments, disabilities and handicaps: a manual of classification relating to the consequences of disease
(1980)ATS/ACCP statement on cardiopulmonary exercise testing
Am J Respir Crit Care Med
(2003)- et al.
Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with COPD
Am J Respir Crit Care Med
(1990)
Exertional breathlessness in patients with chronic airflow limitation: the role of hyperinflation
Am Rev Respir Dis
Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease
Am J Respir Crit Care Med
Role of inspiratory capacity on exercise tolerance in COPD patients with and without tidal expiratory flow limitation at rest
Eur Respir J
Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease
Am J Respir Crit Care Med
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Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).
A list of participants is given in the Appendix.
This study was supported by Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany, and Pfizer, Inc., New York, NY.
Drs. Maltais, Marciniuk, Hernandez, Sciurba, and O'Donnell have received fees from Boehringer Ingelheim for participating in clinical research, advisory board meetings, and continuing medical education events. Drs. Kesten and Hamilton are employees of Boehringer Ingelheim.