Chest
Clinical InvestigationsCOPD and Incident Cardiovascular Disease Hospitalizations and Mortality: Kaiser Permanente Medical Care Program
Section snippets
Study Setting
The study population was drawn from members of the KPNC, aged ≥ 40 years. The KPNC provides comprehensive prepaid integrated health care to its approximately 3.2 million subscribers, who comprise > 25% of the population in the areas served. The subscribers are ethnically, racially, and socioeconomically heterogeneous, and are reflective of the local population except for being somewhat more educated, on average, and underrepresentative of the extremes of income.12 In the age group targeted for
Results
We identified a total of 45,966 persons, age ≥ 40 years who satisfied the case definition for COPD. The gender and age distribution of case patients and control subjects are shown in Table 1. Fifty-five percent of the case patients were men. The mean age of case patients and control subjects was 64.4 years (SD, 12.2 years).
The prevalence at baseline of comorbidities in case patients and control subjects is shown in Table 2. The COPD case group had a higher prevalence of each of the comorbid
Discussion
The main finding of this study was that persons with diagnosed and treated COPD identified in this large integrated health-care population had a higher risk of incident hospitalization and mortality for each of the CVD end points studied, relative to age-matched and gender-matched control subjects. All rates for CVD end points were substantially higher in case patients than in control subjects, most notably so for CHF. Relative to the control subjects, the prevalence of baseline medical
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Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).
This research was funded by grants from Pfizer, Inc. and Boehringer Ingelheim, Inc.