Chest
Clinical InvestigationsMid-Arm Muscle Area Is a Better Predictor of Mortality Than Body Mass Index in COPD
Section snippets
Subjects
A prospective study was made of a cohort of 114 patients with stable COPD. The patients were recruited in the last trimester of the year 2000, with a subsequent follow-up period of 3 years. The diagnosis of COPD was based on a current or previous smoking history (> 20 packs-year), clinical assessment, and pulmonary function testing.17 The postbronchodilator FEV1, expressed as a percentage of the theoretical value, was used to classify the patients according to Global Initiative for Chronic
Subject Characteristics
A total of 114 patients with a diagnosis of COPD were studied. Of these, 18 patients (15.8%) were excluded for different reasons: 7 patients (6.1%) with decompensated cor pulmonale, 3 patients (2.6%) with liver cirrhosis, 2 patients (1.7%) with neoplasms, 2 patients (1.7%) due to sustained oral corticosteroid use, 2 patients (1.7%) because of heart failure, 1 patient (0.9%) with chronic renal failure, and another patient (0.9%) due to malabsorption syndrome. A total of 96 patients were
Discussion
The present study confirms previous data on the effect of muscle mass on mortality in patients with COPD. In stable patients, MD is associated to an increased risk of death. In addition, as a remarkable finding, we show that the prognostic influence of muscle mass can be assessed by determining the MAMA, an inexpensive, simple, and rapidly obtained anthropometric measure. MAMA ≤ p25 was found to be a poor prognosis marker, exerting an influence in our series superior to that of other
References (40)
- et al.
Prevalencia de la desnutrición en pacientes ambulatorios con enfermedad pulmonar obstructiva crónica estable
Arch Bronconeumol
(2004) - et al.
Relationship between respiratory muscle strength and lean body mass in men with COPD
Chest
(1995) - et al.
Tissue depletion and health related quality of life in patients with chronic obstructive pulmonary disease
Respir Med
(2000) - et al.
A new method of classifying prognostic comorbidity in longitudinal studies: development and validation
J Chronic Dis
(1987) - et al.
The measurement of dyspnea: contents, interobserver agreement, and physiologic correlates of two new indexes
Chest
(1984) New norms of upper limb fat and muscle areas for assessment of nutritional status
Am J Clin Nutr
(1981)- et al.
Anthropometric measurements of muscle mass: revised equations for calculating bone-free arm muscle-area
Am J Clin Nutr
(1982) - et al.
Skeletal muscle weakness is associated with wasting of extremity fat-free mass but not with airflow obstruction in patients with chronic obstructive pulmonary disease
Am J Clin Nutr
(2000) - et al.
Predictors of survival in patients receiving domiciliary oxygen therapy or mechanical ventilation: a 10-year analysis of the ANTADIR observatory
Chest
(1996) - et al.
Mortality after hospitalization for COPD
Chest
(2002)
Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD
Chest
Prognostic value of nutritional status in chronic obstructive pulmonary disease
Am J Respir Crit Care Med
Nutritional status and mortality in chronic obstructive pulmonary disease
Am J Respir Crit Care Med
Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease
Am J Respir Crit Care Med
Prognostic value of weight change in chronic obstructive pulmonary disease: results from the Copenhagen City Heart Study
Eur Respir J
The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
N Engl J Med
Prevalence and characteristics of nutritional depletion in patients with stable COPD eligible for pulmonary rehabilitation
Am Rev Respir Dis
Peripheral muscle weakness in patients with chronic obstructive pulmonary disease
Am J Respir Crit Care Med
Nutritional depletion in relation to respiratory and peripheral skeletal muscle function in an outpatient population with chronic obstructive pulmonary disease
Eur Respir J
Peak exercise response in relation to tissue depletion in patients with chronic obstructive pulmonary disease
Eur Respir J
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Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).
This work was performed at Hospital General de Requena, Unidad de Neumología, Servicio de Medicina Interna, Valencia, Spain.