Chest
Original ResearchCOPDLongitudinal Changes in Handgrip Strength, Hyperinflation, and 6-Minute Walk Distance in Patients With COPD and a Control Group
Section snippets
Results
Patients and control subjects were similar in age, sex, height, weight, and BMI (Table 1). As expected, the patients with COPD presented with significantly (P < .01) lower values of FEV1, FEV1/FVC, and diffusing capacity of lung for carbon monoxide than the control subjects, without significant changes after 1-year follow-up. HGS was reduced in the COPD group compared with the control group at visit 1 (32 ± 11.1 kg vs 53 ± 2.6 kg; P «.01) and visit 2 (28 ± 9.2 kg vs 53 ± 2.7 kg; P < .01).
Discussion
This study of patients with COPD has three novel findings. First, a strong association exists between upper- and lower-extremity muscle impairment and static hyperinflation depicted by IC/TLC. Second, the degree of hyperinflation and muscle function impairment worsens over 1 year of observation, with relative preservation of the obstructive degree of lung function (FEV1). Third, decline in HGS and 6MWD and worsened IC/TLC were associated with increased heart rate at rest, showing that patients
Acknowledgments
Author contributions: V. P.-P. had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis, including and especially any adverse effects. F. C. and B. C. contributed to the study design, data analysis and interpretation, and writing of the manuscript; M. D. contributed to the data collection, data analysis and interpretation, and review of the manuscript; and V. P.-P. contributed to the study design, data
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2021, Respiratory InvestigationCitation Excerpt :In the present study, the 4mGS correlated with the IC and the IC/TLC ratio, which are indicators of respiratory failure. In a previous study, more hyperinflation (IC/TLC ratio, <0.25) was associated with a lower 6MWT and handgrip strength in patients with COPD [19]. Here, there was a correlation between the 4mGS and the 6MWT.
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FUNDING/SUPPORT: The authors have reported to that no funding was received for this study.
originally published Online First May 21, 2015.