Chest
Mucormycosis of the Trachea: An Unusual Cause of Acute Upper Airway Obstruction
Section snippets
CASE REPORT
A 20-year-old white woman with insulin-dependent diabetes mellitus presented to the hospital with a one-week history of sore throat which was being treated with oral penicillin. On admission, she was lethargic and febrile (100° F [37.7°C] orally) and physical examination revealed dry mucous membranes with a markedly erythematous pospharynx. Serum glucose was 475 mg/dl and the serum acetone was present at 1:32 dilutions.
The patient was begun on intravenous fluid replacement, antimicrobials and
Discussion
Human infection with mucormycosis most often occurs in a setting of impaired host resistance. While the rhinocerebral form is most common in diabetics, pulmonary mucormycosis is associated with leukemia or lymphoma in over 75 percent of the cases. The remaining cases are associated with diabetes, solid malignancies, chronic systemic disorders, and other disease entities treated with immuno-suppressive therapy. There have been two reports of pulmonary mucormycosis in otherwise healthy patients.12
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Cited by (31)
Tracheal, laryngeal and pulmonary mucormycosis followed by organizing pneumonia in a patient with Adult Onset Still's Disease
2018, Medical Mycology Case ReportsCitation Excerpt :However, medical management with liposomal amphotericin B and posaconazole led to a favorable outcome. In contrast, in six of seven other previously reported cases of tracheal mucormycosis, endoscopic debridement [4] or surgical debridement and/or resection [2,3,7–9] were performed in addition to conventional or liposomal amphotericin B. Five of these six patients survived, but two of them retained a tracheostomy after 4 months and 9 months, respectively [8,9]. Only one patient developed a fulminant disease course and died before any surgical intervention could be attempted [10].
Mucormycoses
2016, Infectious Disease Clinics of North AmericaCitation Excerpt :disseminated; 6. other (uncommon) presentations, such as peritonitis (especially in the setting of peritoneal dialysis),71–73 tracheitis,74 mediastinitis,75–77 renal abscess,78 osteomyelitis,79 myocarditis,80 endocarditis,81 otitis externa,82 keratitis,82 and isolated brain abscess in intravenous drug users.43 Sinusitis occurs more frequently in patients with poorly controlled diabetes, whereas PM is more common in patients with HM.9,21
Agents of Mucormycosis and Entomophthoramycosis
2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious DiseasesTracheal Mucormycosis
2009, Archivos de BronconeumologiaZYGOMYCOSIS
2009, Feigin and Cherry's Textbook of Pediatric Infectious Diseases, Sixth EditionInvasive Zygomycosis: Update on Pathogenesis, Clinical Manifestations, and Management
2006, Infectious Disease Clinics of North AmericaCitation Excerpt :In all cases of catheter-related zygomycosis, prompt removal of the catheter and use of systemic antifungal therapy for several weeks are essential. Reports describing isolated zygomycosis of the trachea [64], mediastinum [65,66], kidney [67], or bone [68] are rare. Intravenous drug abuse is the typical risk factor for both native and prosthetic valve Zygomycetes endocarditis [69–72] and brain abscess (typically involving the basal ganglia) in the absence of concomitant pneumonia [6].