Chest
Clinical Investigations in Critical CareHeat and Moisture Exchangers and Vaporizing Humidifiers in the Intensive Care Unit
Section snippets
METHODS
This study was approved by the Committee on Human Research of our institution. From January to August 1987, we included in the study all patients admitted to the ICU, in whom a controlled MV (CMV) of more than 24 hours was planned. This was done to avoid including patients admitted for a short-term (overnight) postoperative MV. No patient was excluded because of prognosis, diagnosis or presence of pulmonary infection. They were randomly assigned to one of two groups.
Patients in the PUBCF group
RESULTS
The study was interrupted after the death of a patient in the PUBCF group from a total obstruction of his TT. Replacement of the TT was unsuccessful despite the combined efforts of three critical care physicians. Results of the 31 patients included in the PUBCF group and the 42 patients included in the HHWS group are reported. In the PUBCF group, 299 days of ventilation were analyzed and 589 days in the HHWS group. Homogeneity between the PUBCF and the HHWS groups was controlled for the
DISCUSSION
This prospective, randomized, controlled study clearly demonstrates the increased risk of TT occlusion in ICU patients submitted to prolonged CMV with a PUBCF. Clinical reports on the potential benefits or hazards associated with the use of HMEs in ICU patients are limited. Most studies included only intraoperative or stable postoperative patients.20, 21, 22 Since these patients did not present with pathologic lungs or required less than 10 L/minute volume, definite conclusions cannot be drawn
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Manuscript received February 13; revision accepted June 19.