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Droplets Produced by Medical Nebulizers: Some Factors Affecting Their Size and Solute Concentration
Section snippets
METHODS
The following products were assessed: Cadema nebulizer (Cadema Medical Products Inc., Middletown, NY) with compressed oxygen at 8 L/min; Up-Draft nebulizer (Hudson Up-Draft Oxygen Therapy Sales Co., Temecula, CA) with compressed oxygen at 8 L/ min: Up-Draft with Flatus Mk.V air compressor (Mavmed, Anaesthetic Supplies Pty. Ltd, Sydney, Australia)—this system is equivalent to Tote-A-Neb, Hospitak Inc., Lindenhurst, NY (private communication, Laura Martinazzi); Up-Draft with Aerosol-One air
RESULTS
The fall in temperature with time of nebulization for each of the nebulizer-generator systems is shown in Figure 1. For the jet nebulizers, the temperature falls to a steady value Ts which is 5 to 6°C below the ambient temperature at the lower flow rates of the air compressors, and 11 to 15°C at 8 L/min flow rate from a gas cylinder. Most of this temperature change occurs in the first 4 min of aerosol generation. By contrast, the ultrasonic nebulizer increases in temperature by approximately
DISCUSSION
The fact that the nebulizer solution temperature of jet nebulizers falls during generation has been well documented. The heat loss is due to the evaporation of the nebulizer solution to saturate the gas used to generate the aerosol and some cooling due to adiabatic expansion of the generating gas.14, 18 This evaporation also leads to an increase in solute concentration of the nebulizer solution.18 The gas from a compressed gas cylinder contains no water vapor, while an air compressor supplies
ACKNOWLEDGEMENT
The authors would like to thank Mr. Ian Spiers for the preliminary data on the Mist-O2-Gen ultrasonic nebulizer, colleagues in the Departments of Thoracic and Nuclear Medicine at the Royal Prince Alfred Hospital Camperdown for assistance and encouragement, and the Asthma Foundation of New South Wales for financial support.
REFERENCES (29)
- et al.
Output characteristics from three medical nebulizers
J Aerosol Sci
(1986) Physico-chemical studies on aerosol solutions for drug delivery: I
Water-propylene glycol systems. Int J Pharm
(1978)- et al.
Effect of evaporation on the size distribution of nebulized aerosols
J Aerosol Sci
(1977) - et al.
Standardisation of inhalation provocation tests: influence of nebulizer output, particle size and method of inhalation
J Allergy Clin Immunol
(1981) - et al.
Droplet size distributions of nebulized aerosols for inhalation therapy
Clin Phys Physiol Meas
(1986) - et al.
Flow pressure characteristics of compressors used for inhalation therapy
Eur J Respir Dis
(1987) - et al.
Comparison of lung deposition of a solution after nebulization by three commonly portable nebulizers
Pharm Weekblad Sci
(1983) - et al.
Pulmonary deposition of aerosols by different mechanical devices
Respiration
(1985) - et al.
Deposition of carbenicillin aerosols in cystic fibrosis: effects of nebulizer system and breathing pattern
Thorax
(1988) - et al.
Evaluation of jet nebulizers for use with gentamicin solution
Thorax
(1985)
A rapid method for the evaluation of radioaerosol delivery systems
Eur J Nuc Med
Deposition pattern of droplets from medical nebulizers in the human respiratory tract
Bull Europ Physiopath Resp
Comparison of experimental and calculated data for the total and regional deposition in the human lung
J Aerosol Sci
Quantitative deposition of aerosolized gentamicin in cystic fibrosis
Am Rev Respir Dis
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Manuscript received July 18; revision accepted December 1.