Abstract
HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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3' Untranslated Regions
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Alleles
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Asthma / genetics*
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Asthma / immunology*
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Base Sequence
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Binding Sites / genetics
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Female
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Genetic Predisposition to Disease
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Genotype
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HLA Antigens / genetics*
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HLA-G Antigens
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Histocompatibility Antigens Class I / genetics*
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Humans
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Linkage Disequilibrium
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Male
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MicroRNAs / chemistry
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MicroRNAs / genetics*
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MicroRNAs / metabolism
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Polymorphism, Single Nucleotide
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Risk Factors
Substances
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3' Untranslated Regions
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HLA Antigens
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HLA-G Antigens
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Histocompatibility Antigens Class I
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MicroRNAs