Relapsing Rhodococcus equi infection in a heart transplant recipient successfully treated with long-term linezolid

Diagn Microbiol Infect Dis. 2008 Feb;60(2):197-9. doi: 10.1016/j.diagmicrobio.2007.09.004. Epub 2007 Oct 18.

Abstract

We report a heart transplant recipient with Rhodococcus equi and Cryptococcus neoformans infection. Despite an initially relapsing course and the acquisition of resistance in vivo, the patient responded to 5 months of linezolid and 6 months of fluconazole. This is the 1st R. equi infection to be cured with linezolid in a heart transplant recipient.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / therapeutic use*
  • Actinomycetales Infections / drug therapy*
  • Actinomycetales Infections / microbiology*
  • Anti-Bacterial Agents / therapeutic use*
  • Cryptococcosis / drug therapy
  • Cryptococcosis / microbiology
  • Cryptococcus neoformans / drug effects
  • Cryptococcus neoformans / isolation & purification
  • Drug Resistance, Bacterial
  • Fluconazole / therapeutic use
  • Heart Diseases / complications
  • Humans
  • Linezolid
  • Male
  • Middle Aged
  • Oxazolidinones / therapeutic use*
  • Recurrence
  • Rhodococcus equi / drug effects
  • Rhodococcus equi / isolation & purification*
  • Transplantation*
  • Treatment Outcome

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • Fluconazole
  • Linezolid