Spirometry is difficult for some COPD patient to perform. Volumetric capnography could be a second choice test to evaluate the severity of functional disturbances. The aim of this work is to test this hypothesis. A total number of 98 subjects were classified either as normal ex-smokers (N=14) or COPD patients. The latter were staged following GOLD recommendations. Spirometry and volumetric capnography recordings were obtained from each patient. Spirometry parameters, Bohr Dead Space (V(D)Bohr), Airways Dead Space from the pre-interface expirate corrected curve (V(D)aw), Phase III slope (Sl(III)) and Volume of alveolar ejection (V(AE)) were measured. Index of Ventilatory Efficiency (IVE), and Index of Airways Heterogeneity (IAH) were calculated as: IVE = V(AE)/(V(T) - V(D)aw) and IAH = 1-[(V(T)-V(D)Bohr)/(V(T) - V(D)aw)]. In ANOCOVA analysis IAH showed the greatest association with stage (F >40), with no significant covariant dependence on V(T). A receiver operating characteristics curve analysis showed values of the area under the curve greater than 0.9 for IAH and IVE at all stage levels, with a sensitivity = specificity value greater than 80%. We conclude that IAH and IVE can be used when spirometry cannot be reliably performed, as an alternative test to evaluate the degree of functional involvement in COPD patients.