Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; synthesis, structure-activity relationships and in vivo study

J Antibiot (Tokyo). 2012 Sep;65(9):487-90. doi: 10.1038/ja.2012.51. Epub 2012 Jul 4.

Authors

Akihiro Sugawara¹, Akito Sueki, Tomoyasu Hirose, Hideaki Shima, Kiyoko S Akagawa, Satoshi Omura, Toshiaki Sunazuka

Affiliation

¹ Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.

PMID: 22760298
DOI: 10.1038/ja.2012.51

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents / chemical synthesis*
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / pharmacology*
Cell Line, Tumor
Crohn Disease / drug therapy
Dose-Response Relationship, Drug
Humans
Immunologic Factors / chemical synthesis*
Immunologic Factors / chemistry
Immunologic Factors / pharmacology*
Macrolides / chemical synthesis*
Macrolides / chemistry
Macrolides / pharmacology*
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship

Substances

Anti-Inflammatory Agents
Immunologic Factors
Macrolides