Regulatory T cells in the treatment of disease

A Sharabi, MG Tsokos, Y Ding, TR Malek… - Nature reviews Drug …, 2018 - nature.com
Regulatory T (T reg ) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving transplanted …

T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy

A Sharabi, GC Tsokos - Nature Reviews Rheumatology, 2020 - nature.com
T cell subsets are critically involved in the development of systemic autoimmunity and organ
inflammation in systemic lupus erythematosus (SLE). Each T cell subset function (such as …

The effect of the presence of fibromyalgia on common clinical disease activity indices in patients with psoriatic arthritis: a cross-sectional study

…, H Matz, A Polachek, O Elalouf, A Sharabi… - The Journal of …, 2016 - jrheum.org
Objective. To study the effect of the presence of fibromyalgia (FM) on common clinical
disease activity indices in patients with psoriatic arthritis (PsA). Methods. Seventy-three …

Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route

A Sharabi, E Cohen, J Sulkes… - British journal of clinical …, 2003 - Wiley Online Library
Aims To compare the efficacy of sublingual and oral administration of 500 µg of cobalamin
in subjects with cobalamin deficiency. Materials and results Thirty subjects with low serum …

[HTML][HTML] Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells

…, IE Stillman, Z Herbert, JJ Moon, A Sharabi… - Nature …, 2020 - nature.com
Mature double negative (DN) T cells are a population of αβ T cells that lack CD4 and CD8
coreceptors and contribute to systemic lupus erythematosus (SLE). The splenic marginal zone …

[HTML][HTML] Adult-onset Still's disease following mRNA COVID-19 vaccination

A Sharabi, S Shiber, Y Molad - Clinical Immunology (Orlando, Fla.), 2021 - ncbi.nlm.nih.gov
3. Discussion These two cases of AOSD developing after the BNT162b2 mRNA Covid-19
Vaccine (Pfizer) represent a rare phenomenon. Indeed, both of our patients had some degree …

Empowering regulatory T cells in autoimmunity

IR Kasper, SA Apostolidis, A Sharabi… - Trends in molecular …, 2016 - cell.com
Regulatory T cells (Tregs) are capable of dampening immune-mediated inflammation and
avert the destructive effects of uncontrolled inflammation. Distinct molecules and pathways, …

A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4+CD25+ cells and TGF-β

A Sharabi, H Zinger, M Zborowsky… - Proceedings of the …, 2006 - National Acad Sciences
Systemic lupus erythematosus is an autoimmune disease characterized by autoantibodies
and systemic clinical manifestations. A peptide, designated hCDR1, based on the …

[HTML][HTML] Precision DNA demethylation ameliorates disease in lupus-prone mice

H Li, MG Tsokos, S Bickerton, A Sharabi, Y Li… - JCI insight, 2018 - ncbi.nlm.nih.gov
Defective DNA methylation in T cells leads to a series of T cell abnormalities in lupus; however,
the full effect of T cell lineage–specific DNA methylation on disease expression has not …

The serine/threonine protein phosphatase 2A controls autoimmunity

A Sharabi, IR Kasper, GC Tsokos - Clinical Immunology, 2018 - Elsevier
Protein phosphatase 2A (PP2A) is the first serine/threonine phosphatase recognized to
contribute to human and murine lupus immunopathology. PP2A expression in SLE is controlled …