Thyroid and bone

AI Gogakos, JHD Bassett, GR Williams - Archives of biochemistry and …, 2010 - Elsevier
The hypothalamic–pituitary–thyroid axis plays a key role in skeletal development, acquisition
of peak bone mass and regulation of adult bone turnover. Euthyroid status is essential for …

Subclinical thyroid dysfunction and fracture risk: a meta-analysis

…, RN Luben, M Imaizumi, AP Bremner, A Gogakos… - Jama, 2015 - jamanetwork.com
Importance Associations between subclinical thyroid dysfunction and fractures are unclear
and clinical trials are lacking. Objective To assess the association of subclinical thyroid …

[HTML][HTML] Heimlich valve and pneumothorax

A Gogakos, N Barbetakis, G Lazaridis… - Annals of …, 2015 - ncbi.nlm.nih.gov
The Heimlich valve is a small one-way valve used for chest drainage that empties into a
flexible collection device and prevents return of gases or fluids into the pleural space. The …

Bone turnover and bone mineral density are independently related to selenium status in healthy euthyroid postmenopausal women

A Hoeg, A Gogakos, E Murphy, S Mueller… - The Journal of …, 2012 - academic.oup.com
Context: Selenium status may have direct effects on bone and indirect effects through
changes in thyroid hormone sensitivity. Objective: We hypothesized that variation in selenium …

Pediatric aspects in Graves' orbitopathy.

AI Gogakos, K Boboridis, GE Krassas - … endocrinology reviews: PER, 2010 - europepmc.org
Although pediatric Graves' disease is an uncommon condition, children have about the same
(or slightly increased) risk as adults to develop Graves' ophthalmopathy (GO) once they …

Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts

…, F Rivadeneira Ramirez, A Gogakos… - Journal of internal …, 2018 - Wiley Online Library
Background Subclinical hyperthyroidism ( SH yper) has been associated with increased risk
of hip and other fractures, but the linking mechanisms remain unclear. Objective To …

[HTML][HTML] Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength

JHD Bassett, A Gogakos, JK White, H Evans… - 2012 - journals.plos.org
Osteoporosis is a common polygenic disease and global healthcare priority but its genetic
basis remains largely unknown. We report a high-throughput multi-parameter phenotype …

Genetic evidence that thyroid hormone is indispensable for prepubertal insulin‐like growth factor–I expression and bone acquisition in mice

…, C Long, JHD Bassett, A Gogakos… - Journal of bone and …, 2012 - academic.oup.com
Understanding how bone growth is regulated by hormonal and mechanical factors during
early growth periods is important for optimizing the attainment of peak bone mass to prevent or …

Thyroid function tests in the reference range and fracture: individual participant analysis of prospective cohorts

…, RN Luben, AP Bremner, A Gogakos… - The Journal of …, 2017 - academic.oup.com
Context Hyperthyroidism is associated with increased fracture risk, but it is not clear if lower
thyroid-stimulating hormone (TSH) and higher free thyroxine (FT4) in euthyroid individuals …

Thyrostimulin regulates osteoblastic bone formation during early skeletal development

…, A van der Spek, JG Logan, A Gogakos… - …, 2015 - academic.oup.com
The ancestral glycoprotein hormone thyrostimulin is a heterodimer of unique glycoprotein
hormone subunit alpha (GPA)2 and glycoprotein hormone subunit beta (GPB)5 subunits with …