Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial

…, T Starner, C Lux, T Carver, R Thompson… - The lancet Respiratory …, 2019 - thelancet.com
Background Inhaled hypertonic saline enhances mucociliary clearance, improves lung
function, and reduces pulmonary exacerbations in people with cystic fibrosis older than age 6 …

[HTML][HTML] The association of pediatric cystic fibrosis-related diabetes screening on clinical outcomes by center: a CF patient registry study

EF Thompson, D Watson, CM Benoit, S Landvik… - Journal of Cystic …, 2020 - Elsevier
Background Cystic fibrosis related diabetes (CFRD) has been associated with pulmonary
function decline, nutritional status decline and increased mortality. In 2010, the CFRD Clinical …

Measurement of the Heterocyclic Amines 2-Amino-9H-pyrido[2,3-b]indole and 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Urine: Effects of Cigarette …

…, Y Tang, EA Franck Thompson… - Chemical research in …, 2015 - ACS Publications
2-Amino-9H-pyrido[2,3-b]indole (AαC) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
(PhIP) are carcinogenic heterocyclic aromatic amines (HAAs) formed during the …

Objective measures of vest therapy adherence among pediatric subjects with cystic fibrosis

…, AJ Nickel, S Shogren, M Johnson, EF Thompson… - Respiratory …, 2020 - rc.rcjournal.com
BACKGROUND: Airway clearance techniques (ACTs), including high-frequency chest wall
oscillation (vest therapy), are important for maintaining lung function for patients with cystic …

Depletion of Limiting rDNA Structural Complexes Triggers Chromosomal Instability and Replicative Aging of Saccharomyces cerevisiae

RD Fine, N Maqani, M Li, E Franck, JS Smith - Genetics, 2019 - academic.oup.com
Sir2 is a highly conserved NAD + -dependent histone deacetylase that functions in
heterochromatin formation and promotes replicative life span (RLS) in the budding yeast, …

Competition for a limited pool of cohesin between centromeres and the rDNA triggers chromosomal instability that shortens replicative lifespan

RD Fine, N Maqani, M Li, E Franck, JS Smith - bioRxiv, 2018 - biorxiv.org
Sir2 is a highly conserved NAD + -dependent histone deacetylase that functions in
heterochromatin formation and promotes replicative lifespan (RLS) in the budding yeast, …

[HTML][HTML] Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes

…, AJ Tam, R Blosser, ED Thompson… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Current therapy for osteosarcoma pulmonary metastases (PMs) is ineffective.
The mechanisms that prevent successful immunotherapy in osteosarcoma are incompletely …

Intratumoral adaptive immunosuppression and type 17 immunity in mismatch repair proficient colorectal tumors

…, BR Bartlett, LK Aulakh, ED Thompson… - Clinical Cancer …, 2019 - AACR
Purpose: Approximately 10% of patients with mismatch repair–proficient (MMRp) colorectal
cancer showed clinical benefit to anti-PD-1 monotherapy (NCT01876511). We sought to …

Immunopathologic stratification of colorectal cancer for checkpoint blockade immunotherapy

…, Q Zhu, BR Bartlett, LK Aulakh, ED Thompson… - Cancer immunology …, 2019 - AACR
Mismatch-repair deficiency in solid tumors predicts their response to PD-1 blockade. Based
on this principle, pembrolizumab is approved as standard of care for patients with …

[HTML][HTML] Activated iNKT Cells Promote Memory CD8+ T Cell Differentiation during Viral Infection

EC Reilly, EA Thompson, S Aspeslagh, JR Wands… - PloS one, 2012 - journals.plos.org
α-galactosylceramide (α-GalCer) is the prototypical lipid ligand for invariant NKT cells.
Recent studies have proposed that α-GalCer is an effective adjuvant in vaccination against a …