[HTML][HTML] Immune evasion in cancer: Mechanistic basis and therapeutic strategies

…, A Bilsland, D Bhakta, D Halicka, H Fujii… - Seminars in cancer …, 2015 - Elsevier
Cancer immune evasion is a major stumbling block in designing effective anticancer
therapeutic strategies. Although considerable progress has been made in understanding how …

[HTML][HTML] Broad targeting of resistance to apoptosis in cancer

…, JD Morre, HM Coley, K Honoki, H Fujii… - Seminars in cancer …, 2015 - Elsevier
Apoptosis or programmed cell death is natural way of removing aged cells from the body. Most
of the anti-cancer therapies trigger apoptosis induction and related cell death networks to …

[HTML][HTML] Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

…, PJ Vlachostergios, S Guo, K Honoki, H Fujii… - Seminars in cancer …, 2015 - Elsevier
Proliferation is an important part of cancer development and progression. This is manifest
by altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

[HTML][HTML] Broad targeting of angiogenesis for cancer prevention and therapy

…, D Ribatti, YC Chen, K Honoki, H Fujii… - Seminars in cancer …, 2015 - Elsevier
Deregulation of angiogenesis – the growth of new blood vessels from an existing vasculature
– is a main driving force in many severe human diseases including cancer. As such, tumor …

Synthesis of ligand-stabilized silicon nanocrystals with size-dependent photoluminescence spanning visible to near-infrared wavelengths

…, MR Rasch, BW Goodfellow, J Wei, H Fujii… - Chemistry of …, 2012 - ACS Publications
We report a chemical route to colloidal silicon (Si) nanocrystals, or quantum dots, with widely
tunable average diameter, from less than 3 nm up to 90 nm and peak photoluminescence (…

[HTML][HTML] Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

…, CS Boosani, S Chen, MR Ciriolo, H Fujii… - Seminars in cancer …, 2015 - Elsevier
Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways, such …

[HTML][HTML] Cancer prevention and therapy through the modulation of the tumor microenvironment

…, S Chen, MR Ciriolo, S Crawford, H Fujii… - Seminars in cancer …, 2015 - Elsevier
Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …

[HTML][HTML] Designing a broad-spectrum integrative approach for cancer prevention and treatment

…, C Fimognari, GL Firestone, C Frezza, H Fujii… - Seminars in cancer …, 2015 - Elsevier
Targeted therapies and the consequent adoption of “personalized” oncology have achieved
notable successes in some cancers; however, significant problems remain with this …

Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines

H Fujii, K Honoki, T Tsujiuchi… - International …, 2009 - spandidos-publications.com
The presence of cancer stem cells in both solid and hematopoietic malignancies, has been
recently linked to their pathogenesis. Sarcomas are rare, and diversely characterized by …

Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance

K Honoki, H Fujii, A Kubo, A Kido, T Mori… - Oncology …, 2010 - spandidos-publications.com
Elevated aldehyde dehydrogenase 1 (ALDH1) has been proposed as one of the possible
candidates for a stem cell maker that can be used for the isolation of cancer stem cells from …