Rationale: Evidence suggests that tumor necrosis factor (TNF)-α plays an important role in
the pathophysiology of sarcoidosis. Objectives: To assess the efficacy of infliximab in …

Background Tiotropium, a once-daily anticholinergic, and salmeterol represent two inhaled,
long-acting bronchodilators from different pharmacologic classes. A trial was designed to …

Study objectives To examine and compare the efficacy and safety of salmeterol xinafoate, a
long-acting inhaledβ 2 -adrenergic agonist, with inhaled ipratropium bromide and inhaled …

… Correspondence and requests for reprints should be addressed to James F. Donohue, MD,
University of North Carolina, 4125 BioInformatics Building, 130 Mason Farm Road, CB 7020, …

Rationale: Chronic obstructive pulmonary disease (COPD) is a progressive, smoking-related,
inflammatory lung disease in which tumor necrosis factor-α is overexpressed and has …

The FEV 1 is widely used by physicians in the diagnosis, staging, treatment, monitoring and
establishing prognosis for patients with COPD. The MCID is the smallest difference which …

Simulation results of microparticle and nanoparticle deposition patterns, local concentrations,
and segmental averages are contrasted for a human upper airway model starting from the …

Study objective To examine the efficacy and safety of the once-daily, inhaled, long-acting
muscarinic antagonist/β 2 -agonist combination umeclidinium/vilanterol (UMEC/VI) compared …

Rationale: An antagonist (MK-7123) of the cytokine receptor CXCR2 reduces neutrophil
chemotaxis and thus may alleviate airway inflammation in chronic obstructive pulmonary …

Study objectives To describe the health-related quality of life (HRQL) and mental health of
persons with sarcoidosis, as well as to assess physician-patient agreement about the …