Background Whether noninvasive ventilation should be administered in patients with acute
hypoxemic respiratory failure is debated. Therapy with high-flow oxygen through a nasal …

Background The Surviving Sepsis Campaign recommends targeting a mean arterial pressure
of at least 65 mm Hg during initial resuscitation of patients with septic shock. However, …

Background Awake prone positioning has been reported to improve oxygenation for patients
with COVID-19 in retrospective and observational studies, but whether it improves patient-…

Background The timing of renal-replacement therapy in critically ill patients who have acute
kidney injury but no potentially life-threatening complication directly related to renal failure is …

Rationale: One important concern during high-flow nasal cannula (HFNC) therapy in patients
with acute hypoxemic respiratory failure is to not delay intubation. Objectives: To validate …

Background Whether the route of early feeding affects outcomes of patients with severe
critical illnesses is controversial. We hypothesised that outcomes were better with early first-line …

Background International guidelines for management of septic shock recommend that
dopamine or norepinephrine are preferable to epinephrine. However, no large comparative trial …

Background Critically ill patients often require emergency intubation. The use of etomidate as
the sedative agent in this context has been challenged because it might cause a reversible …

Purpose To evaluate the efficiency, safety and outcome of high flow nasal cannula oxygen (HFNC)
in ICU patients with acute respiratory failure. Methods Pilot prospective monocentric …

Importance Coronavirus disease 2019 (COVID-19) is associated with severe lung damage.
Corticosteroids are a possible therapeutic option. Objective To determine the effect of …