Kinase inhibitors show great promise as a new class of therapeutics. Here we describe an
efficient way to determine kinase inhibitor specificity by measuring binding of small molecules …

The acquired immunodeficiency syndrome (AIDS)-causing lentiviruses human immunodeficiency
virus (HIV) and simian immunodeficiency virus (SIV) effectively evade host immunity …

To realize the full potential of targeted protein kinase inhibitors for the treatment of cancer, it
is important to address the emergence of drug resistance in treated patients. Mutant forms of …

Established infections with the human and simian immunodeficiency viruses (HIV and SIV,
respectively) are thought to be permanent with even the most effective immune responses …

Introduction CD8 + T cell responses focus on a small fraction of total pathogen-encoded
peptides, which are similar among individuals with shared major histocompatibility complex (…

Cytomegalovirus (CMV) can superinfect persistently infected hosts despite CMV-specific
humoral and cellular immunity; however, how it does so remains undefined. We have …

Major histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed,
nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in …

Despite widespread use of the bacille Calmette–Guérin (BCG) vaccine, tuberculosis (TB)
remains a leading cause of global mortality from a single infectious agent (Mycobacterium …

Prophylactic vaccination of rhesus macaques with rhesus cytomegalovirus (RhCMV) vectors
expressing simian immunodeficiency virus (SIV) antigens (RhCMV/SIV) elicits immune …

Interactions between kinases and small molecule inhibitors can be activation state
dependent. A detailed understanding of inhibitor binding therefore requires characterizing …